The vascular endothelium serves numerous diverse functions vital to the proper homeostasis of all organs. Beyond providing a conduit for oxygen delivery, the endothelium directs inflammatory cell traffic, controls thrombosis and macromolecular transport, presents a source of and target for cytokines and growth factors, and coordinates angiogenic activity. Accordingly, acute and chronic illnesses that derange endothelial function-such as diabetes mellitus, sepsis, and atherosclerosis-cause widespread, protean, and often severe manifestations of disease. To this list of systemic vascular diseases we add AIDS. The vascular endothelium is a silent target of human immunodeficiency virus-1 (HIV-1), and infection of individuals with HIV-1 results in a series of diffuse vascular processes that frequently progress unrecognized.
|Original language||English (US)|
|Title of host publication||AIDS and Heart Disease|
|Number of pages||17|
|State||Published - Jan 1 2004|
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