TY - JOUR
T1 - Paternal histocompatibility (HLA) antigens and maternal anti-HLA antibodies in herpes gestationis
AU - Shornick, J. K.
AU - Stastny, P.
AU - Gilliam, J. N.
N1 - Funding Information:
Manuscript received November June 6, 1983. • Presented in abstract form J Invest Dermatol 78:340, 1982. This work was supported by grants AM-19101, AM-00730, and AI· 12563 from the National Institutes of Health; lmmunodermatology Center grant AM-17363; Immunodermatology Fellowship grant AM- 07341; and grants from the Dermatology Foundation and the Kroc
PY - 1983
Y1 - 1983
N2 - It has been suggested that anti-HLA antibodies might be involved in the pathogenesis of herpes gestationis (HG). Accordingly, we have studied the frequency and specificity of such antibodies in 26 female patients with immunologically proven HG. In addition, to further investigate the potential association of the husband's antigens in the development of this disorder, we have performed HLA typing in 20 of the husbands of these women. HLA-DR2 was found in 50% of the husbands (controls 25%, p = 0.04). The increase was more pronounced in the husbands of patients with the HLA-DR3, DR4 combination (64%, p < .01) than in the husbands of those with other antigen combinations. Anti-HLA antibodies were found in 85% of women with a history of HG. Approximately 25% of normal, multiparous women have such antibodies in their sera. In normal women, their presence has not been associated with increased fetal or maternal risk. These data suggest that the husband's HLA type may be associated with the development of HG in the wife. Anti-HLA antibodies are present in most patients, but their significance remains uncertain.
AB - It has been suggested that anti-HLA antibodies might be involved in the pathogenesis of herpes gestationis (HG). Accordingly, we have studied the frequency and specificity of such antibodies in 26 female patients with immunologically proven HG. In addition, to further investigate the potential association of the husband's antigens in the development of this disorder, we have performed HLA typing in 20 of the husbands of these women. HLA-DR2 was found in 50% of the husbands (controls 25%, p = 0.04). The increase was more pronounced in the husbands of patients with the HLA-DR3, DR4 combination (64%, p < .01) than in the husbands of those with other antigen combinations. Anti-HLA antibodies were found in 85% of women with a history of HG. Approximately 25% of normal, multiparous women have such antibodies in their sera. In normal women, their presence has not been associated with increased fetal or maternal risk. These data suggest that the husband's HLA type may be associated with the development of HG in the wife. Anti-HLA antibodies are present in most patients, but their significance remains uncertain.
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U2 - 10.1111/1523-1747.ep12522534
DO - 10.1111/1523-1747.ep12522534
M3 - Article
C2 - 6355306
AN - SCOPUS:0021025362
SN - 0022-202X
VL - 81
SP - 407
EP - 409
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -