TY - JOUR
T1 - Partial reversal of barbiturate anesthesia by dopamine antagonism
T2 - An electroencephalographic study
AU - Sinton, Christopher M.
AU - Goeller, Christine J.
PY - 1988/11
Y1 - 1988/11
N2 - The D-1 dopamine antagonist, SCH 23390, was administered to rats under barbiturate anesthesia. Recording of the power frequency spectrum of the electroencephalogram (EEG) showed that the D-1 antagonist shifted the relative power in the EEG to higher frequencies. In contrast, a relatively selective D-2 antagonist, haloperidol, administered under the same conditions, had no effect. These results suggest that SCH 23390 can partially reverse barbiturate anesthesia, and imply that central dopamine, acting at the D-1 site, might modulate this type of anesthetic.
AB - The D-1 dopamine antagonist, SCH 23390, was administered to rats under barbiturate anesthesia. Recording of the power frequency spectrum of the electroencephalogram (EEG) showed that the D-1 antagonist shifted the relative power in the EEG to higher frequencies. In contrast, a relatively selective D-2 antagonist, haloperidol, administered under the same conditions, had no effect. These results suggest that SCH 23390 can partially reverse barbiturate anesthesia, and imply that central dopamine, acting at the D-1 site, might modulate this type of anesthetic.
KW - D-1
KW - D-2
KW - EEG
KW - Haloperidol
KW - Inactin
KW - Ketanserin
KW - Nembutal
KW - SCH 23390
UR - http://www.scopus.com/inward/record.url?scp=0024152394&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024152394&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(88)90053-6
DO - 10.1016/0361-9230(88)90053-6
M3 - Article
C2 - 3064882
AN - SCOPUS:0024152394
SN - 0361-9230
VL - 21
SP - 835
EP - 837
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 5
ER -