PARPs and ADP-ribosylation: 60 years on

W. Lee Kraus

doi:10.1101/gad.336420.120

PARPs and ADP-ribosylation: 60 years on

W. Lee Kraus

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point theway forward for future advances in the field.

Original language	English (US)
Pages (from-to)	251-253
Number of pages	3
Journal	Genes and Development
Volume	34
Issue number	5
DOIs	https://doi.org/10.1101/gad.336420.120
State	Published - Mar 1 2020

Keywords

ADP-ribosylation
PARPs
Posttranslational modification

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.336420.120

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title = "PARPs and ADP-ribosylation: 60 years on",

abstract = "Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point theway forward for future advances in the field.",

keywords = "ADP-ribosylation, PARPs, Posttranslational modification",

author = "Kraus, {W. Lee}",

note = "Funding Information: I thank the members of my laboratory for their continuing discoveries that have helped to increase our understanding of PARPs and ADP-ribosylation. The PARP-related research in W.L.K.{\textquoteright}s laboratory is supported by a grant from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK069710), grants from Cancer Prevention and Research Institute of Texas (RP160319 and RP190236), and funds from the Cecil H. and Ida Green Center for Reproductive Biology Sciences Endowment to W.L.K. Publisher Copyright: {\textcopyright} 2020 Kraus.",

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doi = "10.1101/gad.336420.120",

language = "English (US)",

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PY - 2020/3/1

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N2 - Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point theway forward for future advances in the field.

AB - Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point theway forward for future advances in the field.

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PARPs and ADP-ribosylation: 60 years on

Abstract

Keywords

ASJC Scopus subject areas

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