Paroxysmal cold hemoglobinuria and cardiopulmonary bypass

Alan P. Kypson, John J. Warner, Marilyn J. Telen, Carmelo A. Milano

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Paroxysmal cold hemoglobinuria, a cold-reactive autoimmune disease associated with the Donath-Landsteiner antibody, has not been described in patients undergoing cardiac surgery. We report a case of mitral valve replacement in a woman with a positive Donath-Landsteiner antibody and a history of recurrent hemolysis and hemoglobinuria secondary to cold exposure. Successful perioperative management is described, as is a discussion of paroxysmal cold hemoglobinuria.

Original languageEnglish (US)
Pages (from-to)579-581
Number of pages3
JournalAnnals of Thoracic Surgery
Issue number2
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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