Background. The combined modalities of surgery, chemotherapy, and radiation therapy have greatly improved the survival rate in childhood paratesticular rhabdomyosarcoma, but the incidence of complications and late side effects is a cause for concern. Methods. We reviewed the records of 18 patients treated for paratesticular rhabdomyosarcoma at St. Jude Children's Research Hospital between 1962 and 1989. Patients with Group I disease were treated with orchiectomy, retroperitoneal lymph node dissection, and multiagent chemotherapy; more advanced cases also received radiation therapy with concurrent chemotherapy. Results. Sequelae included esophageal and common bile duct stricture, inguinal nerve entrapment syndrome, and small bowel obstruction. Short stature was found in all children whose spines were irradiated via para‐aortic fields (34–37 Gy) prior to puberty. Two of 18 patients died from treatment complications and one from progressive disease. Conclusions. Multimodality treatment offers an excellent prognosis in paratesticular rhabdomyosarcoma, but is associated with significant morbidity and mortality rates. A discussion of therapy components and their application to disease stages suggests possible approaches to optimizing treatment for this therapy‐sensitive malignancy.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Jan 15 1994|
ASJC Scopus subject areas
- Cancer Research