Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma

Steven Vernino; Eric R. Eggenberger; Lisa R. Rogers; Vanda A. Lennon

doi:10.1212/WNL.59.6.929

Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma

Steven Vernino, Eric R. Eggenberger, Lisa R. Rogers, Vanda A. Lennon

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Neurologic autoimmunity frequently occurs with thymoma, particularly myasthenia gravis and skeletal muscle-specific autoantibodies. Type 1 antineuronal nuclear antibody (ANNA-1/"anti-Hu"), which is recognized as an immunoglobulin G marker of small-cell lung carcinoma, has not been reported with thymoma. The authors identified four patients (three under age 40) with ANNA-1 and a paraneoplastic neurologic complication of thymoma. Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity.

Original language	English (US)
Pages (from-to)	929-932
Number of pages	4
Journal	Neurology
Volume	59
Issue number	6
DOIs	https://doi.org/10.1212/WNL.59.6.929
State	Published - Sep 24 2002

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Neurologic autoimmunity frequently occurs with thymoma, particularly myasthenia gravis and skeletal muscle-specific autoantibodies. Type 1 antineuronal nuclear antibody (ANNA-1/{"}anti-Hu{"}), which is recognized as an immunoglobulin G marker of small-cell lung carcinoma, has not been reported with thymoma. The authors identified four patients (three under age 40) with ANNA-1 and a paraneoplastic neurologic complication of thymoma. Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity.",

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AB - Neurologic autoimmunity frequently occurs with thymoma, particularly myasthenia gravis and skeletal muscle-specific autoantibodies. Type 1 antineuronal nuclear antibody (ANNA-1/"anti-Hu"), which is recognized as an immunoglobulin G marker of small-cell lung carcinoma, has not been reported with thymoma. The authors identified four patients (three under age 40) with ANNA-1 and a paraneoplastic neurologic complication of thymoma. Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity.

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Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma

Abstract

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