Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis

D. C. Metz; W. J. Bochenek; Richard Aaronson; James L. Achord; Dennis Avner; Jose Behar; Mark Blitstein; Saul Feldman; Ralph A. Giannella; William V. Harford; Vernon Hee; James V. Jones; Peter J. Karras; David Kogut; Robert Kornfield; Thomas Kovacs; Thomas Meister; David Metz; Philip Miner; John Orchard; Daniel Pambianco; Anirudh Rai; Richard Redinger; Dennis Riff; John Rodgers; Stanley Rosenberg; Alan Safdi; Paul Schlesinger; Howard I. Schwartz; William Snape; James Wagonfeld; Steven Wilkofsky; Barry D. Winston; Lawrence Wruble; Wallace Wu

doi:10.1046/j.1365-2036.2003.01410.x

Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis

D. C. Metz, W. J. Bochenek, Richard Aaronson, James L. Achord, Dennis Avner, Jose Behar, Mark Blitstein, Saul Feldman, Ralph A. Giannella, William V. Harford, Vernon Hee, James V. Jones, Peter J. Karras, David Kogut, Robert Kornfield, Thomas Kovacs, Thomas Meister, David Metz, Philip Miner, John OrchardDaniel Pambianco, Anirudh Rai, Richard Redinger, Dennis Riff, John Rodgers, Stanley Rosenberg, Alan Safdi, Paul Schlesinger, Howard I. Schwartz, William Snape, James Wagonfeld, Steven Wilkofsky, Barry D. Winston, Lawrence Wruble, Wallace Wu

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Objectives: To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1) erosive oesophagitis. Methods: Patients (371) were randomly assigned to receive pantoprazole 10, 20 or 40 mg or ranitidine 150 mg. Endoscopies were performed after 1, 3, 6 and 12 months or when symptoms suggesting relapse (grade = 2) developed. Gastric biopsies were obtained at baseline and on at least one postbaseline visit. Symptom-free days and Gelusil use were assessed. Results: Pantoprazole was significantly (P < 0.001) more effective in maintaining erosive oesophagitis healing. After 12 months. 33%, 40%, 68% and 82% of patients remained healed for the ranitidine and pantoprazole 10, 20 and 40 mg groups, respectively. Daytime and night-time heartburn were eliminated in > 90% of days for the pantoprazole 40 mg group. Gelusil use was significantly lower with pantoprazole 20 and 40 mg than with ranitidine (P < 0.02) during the first 9 months. Conclusions: Twelve months of maintenance therapy with pantoprazole (10-40 mg once daily) was superior to ranitidine (150 mg twice daily) in maintaining erosive oesophagitis healing. Pantoprazole 40 mg provided the most consistent efficacy and was well tolerated.

Original language	English (US)
Pages (from-to)	155-164
Number of pages	10
Journal	Alimentary Pharmacology and Therapeutics
Volume	17
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2036.2003.01410.x
State	Published - Jan 1 2003

ASJC Scopus subject areas

Hepatology
Gastroenterology
Pharmacology (medical)

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Metz, D. C., Bochenek, W. J., Aaronson, R., Achord, J. L., Avner, D., Behar, J., Blitstein, M., Feldman, S., Giannella, R. A., Harford, W. V., Hee, V., Jones, J. V., Karras, P. J., Kogut, D., Kornfield, R., Kovacs, T., Meister, T., Metz, D., Miner, P., ... Wu, W. (2003). Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis. Alimentary Pharmacology and Therapeutics, 17(1), 155-164. https://doi.org/10.1046/j.1365-2036.2003.01410.x

Metz, DC, Bochenek, WJ, Aaronson, R, Achord, JL, Avner, D, Behar, J, Blitstein, M, Feldman, S, Giannella, RA, Harford, WV, Hee, V, Jones, JV, Karras, PJ, Kogut, D, Kornfield, R, Kovacs, T, Meister, T, Metz, D, Miner, P, Orchard, J, Pambianco, D, Rai, A, Redinger, R, Riff, D, Rodgers, J, Rosenberg, S, Safdi, A, Schlesinger, P, Schwartz, HI, Snape, W, Wagonfeld, J, Wilkofsky, S, Winston, BD, Wruble, L & Wu, W 2003, 'Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis', Alimentary Pharmacology and Therapeutics, vol. 17, no. 1, pp. 155-164. https://doi.org/10.1046/j.1365-2036.2003.01410.x

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abstract = "Objectives: To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1) erosive oesophagitis. Methods: Patients (371) were randomly assigned to receive pantoprazole 10, 20 or 40 mg or ranitidine 150 mg. Endoscopies were performed after 1, 3, 6 and 12 months or when symptoms suggesting relapse (grade = 2) developed. Gastric biopsies were obtained at baseline and on at least one postbaseline visit. Symptom-free days and Gelusil use were assessed. Results: Pantoprazole was significantly (P < 0.001) more effective in maintaining erosive oesophagitis healing. After 12 months. 33%, 40%, 68% and 82% of patients remained healed for the ranitidine and pantoprazole 10, 20 and 40 mg groups, respectively. Daytime and night-time heartburn were eliminated in > 90% of days for the pantoprazole 40 mg group. Gelusil use was significantly lower with pantoprazole 20 and 40 mg than with ranitidine (P < 0.02) during the first 9 months. Conclusions: Twelve months of maintenance therapy with pantoprazole (10-40 mg once daily) was superior to ranitidine (150 mg twice daily) in maintaining erosive oesophagitis healing. Pantoprazole 40 mg provided the most consistent efficacy and was well tolerated.",

author = "Metz, {D. C.} and Bochenek, {W. J.} and Richard Aaronson and Achord, {James L.} and Dennis Avner and Jose Behar and Mark Blitstein and Saul Feldman and Giannella, {Ralph A.} and Harford, {William V.} and Vernon Hee and Jones, {James V.} and Karras, {Peter J.} and David Kogut and Robert Kornfield and Thomas Kovacs and Thomas Meister and David Metz and Philip Miner and John Orchard and Daniel Pambianco and Anirudh Rai and Richard Redinger and Dennis Riff and John Rodgers and Stanley Rosenberg and Alan Safdi and Paul Schlesinger and Schwartz, {Howard I.} and William Snape and James Wagonfeld and Steven Wilkofsky and Winston, {Barry D.} and Lawrence Wruble and Wallace Wu",

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T1 - Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis

AU - Metz, D. C.

AU - Bochenek, W. J.

AU - Aaronson, Richard

AU - Achord, James L.

AU - Avner, Dennis

AU - Behar, Jose

AU - Blitstein, Mark

AU - Feldman, Saul

AU - Giannella, Ralph A.

AU - Harford, William V.

AU - Hee, Vernon

AU - Jones, James V.

AU - Karras, Peter J.

AU - Kogut, David

AU - Kornfield, Robert

AU - Kovacs, Thomas

AU - Meister, Thomas

AU - Metz, David

AU - Miner, Philip

AU - Orchard, John

AU - Pambianco, Daniel

AU - Rai, Anirudh

AU - Redinger, Richard

AU - Riff, Dennis

AU - Rodgers, John

AU - Rosenberg, Stanley

AU - Safdi, Alan

AU - Schlesinger, Paul

AU - Schwartz, Howard I.

AU - Snape, William

AU - Wagonfeld, James

AU - Wilkofsky, Steven

AU - Winston, Barry D.

AU - Wruble, Lawrence

AU - Wu, Wallace

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Objectives: To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1) erosive oesophagitis. Methods: Patients (371) were randomly assigned to receive pantoprazole 10, 20 or 40 mg or ranitidine 150 mg. Endoscopies were performed after 1, 3, 6 and 12 months or when symptoms suggesting relapse (grade = 2) developed. Gastric biopsies were obtained at baseline and on at least one postbaseline visit. Symptom-free days and Gelusil use were assessed. Results: Pantoprazole was significantly (P < 0.001) more effective in maintaining erosive oesophagitis healing. After 12 months. 33%, 40%, 68% and 82% of patients remained healed for the ranitidine and pantoprazole 10, 20 and 40 mg groups, respectively. Daytime and night-time heartburn were eliminated in > 90% of days for the pantoprazole 40 mg group. Gelusil use was significantly lower with pantoprazole 20 and 40 mg than with ranitidine (P < 0.02) during the first 9 months. Conclusions: Twelve months of maintenance therapy with pantoprazole (10-40 mg once daily) was superior to ranitidine (150 mg twice daily) in maintaining erosive oesophagitis healing. Pantoprazole 40 mg provided the most consistent efficacy and was well tolerated.

AB - Objectives: To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1) erosive oesophagitis. Methods: Patients (371) were randomly assigned to receive pantoprazole 10, 20 or 40 mg or ranitidine 150 mg. Endoscopies were performed after 1, 3, 6 and 12 months or when symptoms suggesting relapse (grade = 2) developed. Gastric biopsies were obtained at baseline and on at least one postbaseline visit. Symptom-free days and Gelusil use were assessed. Results: Pantoprazole was significantly (P < 0.001) more effective in maintaining erosive oesophagitis healing. After 12 months. 33%, 40%, 68% and 82% of patients remained healed for the ranitidine and pantoprazole 10, 20 and 40 mg groups, respectively. Daytime and night-time heartburn were eliminated in > 90% of days for the pantoprazole 40 mg group. Gelusil use was significantly lower with pantoprazole 20 and 40 mg than with ranitidine (P < 0.02) during the first 9 months. Conclusions: Twelve months of maintenance therapy with pantoprazole (10-40 mg once daily) was superior to ranitidine (150 mg twice daily) in maintaining erosive oesophagitis healing. Pantoprazole 40 mg provided the most consistent efficacy and was well tolerated.

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Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis

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