TY - JOUR
T1 - Pancreatic alpha cell function in trauma
AU - Lindsey, A.
AU - Santeusanio, F.
AU - Braaten, J.
AU - Faloona, G. R.
AU - Unger, Roger H
PY - 1974
Y1 - 1974
N2 - In a group of 20 consecutive patients hospitalized with severe traumatic shock, mean plasma glucagon levels averaged 328±65 μμg/ml, significantly above the normal fasting levels. Insulin concentration was normal, and plasma glucose levels averaged 188(±14) mg/100 ml, significantly above normal. Insulin glucagon molar ratio was low in 17 of the 20 patients. In 3 patients undergoing major surgery without associated hypotension, glucagon concentrations did not rise comparably. Hyperglucagonemia without a proportional rise in insulin may be the usual islet cell response to severe trauma and possibly could contribute to survival.
AB - In a group of 20 consecutive patients hospitalized with severe traumatic shock, mean plasma glucagon levels averaged 328±65 μμg/ml, significantly above the normal fasting levels. Insulin concentration was normal, and plasma glucose levels averaged 188(±14) mg/100 ml, significantly above normal. Insulin glucagon molar ratio was low in 17 of the 20 patients. In 3 patients undergoing major surgery without associated hypotension, glucagon concentrations did not rise comparably. Hyperglucagonemia without a proportional rise in insulin may be the usual islet cell response to severe trauma and possibly could contribute to survival.
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U2 - 10.1001/jama.227.7.757
DO - 10.1001/jama.227.7.757
M3 - Article
C2 - 4590022
SN - 0098-7484
VL - 227
SP - 757
EP - 761
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 7
ER -