Palmoplantar psoriasis: A phenotypical and clinical review with introduction of a new quality-of-life assessment tool

Elizabeth Farley, Shamin Masrour, Joanna McKey, Alan Menter

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: Palmoplantar psoriasis is associated with significant quality-of-life issues. Its epidemiology and phenotypical expression remain ill defined. Objective: We reviewed the literature and our clinical experience and developed a new quality-of-life assessment tool. Methods: We conducted a retrospective review of 150 patients with palmoplantar psoriasis. Results: In all, 78 (52%) patients displayed predominantly hyperkeratotic palmoplantar lesions, 24 (16%) pustular, 18 (12%) combination, and 30 (20%) had an indeterminate phenotype. In 27 (18%) patients, lesions were confined to the palms and soles. A new quality-of-life index was constructed to characterize disease severity. In all, 27 (18%) had mild, 72 (48%) moderate, and 51 (34%) severe disease involvement. Palmoplantar disease severity appeared independent from the degree of body surface area involvement. Limitations: This was a retrospective review. The quality-of-life index remains to be statistically verified in prospective clinical studies. Conclusion: Defining morphologic subtypes together with the use of a specific quality-of-life assessment tool in patients with palmoplantar psoriasis will improve our understanding and treatment of this recalcitrant form of psoriasis.

Original languageEnglish (US)
Pages (from-to)1024-1031
Number of pages8
JournalJournal of the American Academy of Dermatology
Issue number6
StatePublished - Jun 2009
Externally publishedYes


  • hand and foot questionnaire
  • new assessment tool
  • palmoplantar psoriasis
  • phenotype
  • quality-of-life assessment tool

ASJC Scopus subject areas

  • Dermatology


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