TY - JOUR
T1 - Palmoplantar psoriasis
T2 - A phenotypical and clinical review with introduction of a new quality-of-life assessment tool
AU - Farley, Elizabeth
AU - Masrour, Shamin
AU - McKey, Joanna
AU - Menter, Alan
PY - 2009/6
Y1 - 2009/6
N2 - Background: Palmoplantar psoriasis is associated with significant quality-of-life issues. Its epidemiology and phenotypical expression remain ill defined. Objective: We reviewed the literature and our clinical experience and developed a new quality-of-life assessment tool. Methods: We conducted a retrospective review of 150 patients with palmoplantar psoriasis. Results: In all, 78 (52%) patients displayed predominantly hyperkeratotic palmoplantar lesions, 24 (16%) pustular, 18 (12%) combination, and 30 (20%) had an indeterminate phenotype. In 27 (18%) patients, lesions were confined to the palms and soles. A new quality-of-life index was constructed to characterize disease severity. In all, 27 (18%) had mild, 72 (48%) moderate, and 51 (34%) severe disease involvement. Palmoplantar disease severity appeared independent from the degree of body surface area involvement. Limitations: This was a retrospective review. The quality-of-life index remains to be statistically verified in prospective clinical studies. Conclusion: Defining morphologic subtypes together with the use of a specific quality-of-life assessment tool in patients with palmoplantar psoriasis will improve our understanding and treatment of this recalcitrant form of psoriasis.
AB - Background: Palmoplantar psoriasis is associated with significant quality-of-life issues. Its epidemiology and phenotypical expression remain ill defined. Objective: We reviewed the literature and our clinical experience and developed a new quality-of-life assessment tool. Methods: We conducted a retrospective review of 150 patients with palmoplantar psoriasis. Results: In all, 78 (52%) patients displayed predominantly hyperkeratotic palmoplantar lesions, 24 (16%) pustular, 18 (12%) combination, and 30 (20%) had an indeterminate phenotype. In 27 (18%) patients, lesions were confined to the palms and soles. A new quality-of-life index was constructed to characterize disease severity. In all, 27 (18%) had mild, 72 (48%) moderate, and 51 (34%) severe disease involvement. Palmoplantar disease severity appeared independent from the degree of body surface area involvement. Limitations: This was a retrospective review. The quality-of-life index remains to be statistically verified in prospective clinical studies. Conclusion: Defining morphologic subtypes together with the use of a specific quality-of-life assessment tool in patients with palmoplantar psoriasis will improve our understanding and treatment of this recalcitrant form of psoriasis.
KW - hand and foot questionnaire
KW - new assessment tool
KW - palmoplantar psoriasis
KW - phenotype
KW - quality-of-life assessment tool
UR - http://www.scopus.com/inward/record.url?scp=65649116588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649116588&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2008.11.910
DO - 10.1016/j.jaad.2008.11.910
M3 - Article
C2 - 19467374
AN - SCOPUS:65649116588
SN - 0190-9622
VL - 60
SP - 1024
EP - 1031
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -