Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum

Jaime H. Noguez, Thushara K K Diyabalanage, Yoshinari Miyata, Xiao Song Xie, Frederick A. Valeriote, Charles D. Amsler, James B. McClintock, Bill J. Baker

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Palmerolides D-G are new bioactive macrolides isolated from the Antarctic tunicate Synoicum adareanum and are related to the melanoma-selective cytotoxin palmerolide A. Most of these palmerolides are potent V-ATPase inhibitors and have sub-micromolar activity against melanoma. Though palmerolide A remains the most potent of this series of natural products against mammalian V-ATPase, recent data suggests that palmerolide D is the most potent against melanoma. A comparison of the bioactivity data obtained for these natural product palmerolides has provided insight into the substructures necessary to retain V-ATPase inhibition and cytotoxic activity.

Original languageEnglish (US)
Pages (from-to)6608-6614
Number of pages7
JournalBioorganic and Medicinal Chemistry
Issue number22
StatePublished - Nov 15 2011


  • Melanoma
  • Polyketide
  • V-ATPase inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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