TY - JOUR
T1 - Pallidal low β-low γ phase-amplitude coupling inversely correlates with Parkinson disease symptoms
AU - Tsiokos, Christos
AU - Malekmohammadi, Mahsa
AU - AuYong, Nicholas
AU - Pouratian, Nader
N1 - Funding Information:
This work was supported by the National Institutes of Biomedical Imaging and Bioengineering [ K23 EB014326 ], National Institutes of Neurological Disease and Stroke [ R01NS097782 ], and philanthropic support from Casa Colina Centers for Rehabilitation and postdoctoral fellowship from American Parkinson disease association.
Publisher Copyright:
© 2017 International Federation of Clinical Neurophysiology
PY - 2017/11
Y1 - 2017/11
N2 - Objective Recent discoveries suggest that it is most likely the coupling of β oscillations (13–30 Hz) and not merely their power that relates to Parkinson disease (PD) pathophysiology. Methods We analyzed power and phase amplitude coupling (PAC) in local field potentials (LFP) recorded from Pallidum after placement of deep brain stimulation (DBS) leads in nineteen PD patients and three patients with dystonia. Results Within GPi, we identified PAC between phase of β and amplitude of high frequency oscillations (200–300 Hz) and distinct β-low γ (40–80 Hz) PAC both modulated by contralateral movement. Resting β-low γ PAC, also present in dystonia patients, inversely correlated with severity of rigidity and bradykinesia (R = −0.44, P = 0.028). These findings were specific to the low β band, suggesting a differential role for the two β sub-bands. Conclusions PAC is present across distinct frequency bands within the GPi. Given the presence of low β-low γ PAC in dystonia and the inverse correlation with symptom severity, we propose that this PAC may be a normal pallidal signal. Significance This study provides new evidence on the pathophysiological contribution of local pallidal coupling and suggests similar and distinct patterns of coupling within GPi and STN in PD.
AB - Objective Recent discoveries suggest that it is most likely the coupling of β oscillations (13–30 Hz) and not merely their power that relates to Parkinson disease (PD) pathophysiology. Methods We analyzed power and phase amplitude coupling (PAC) in local field potentials (LFP) recorded from Pallidum after placement of deep brain stimulation (DBS) leads in nineteen PD patients and three patients with dystonia. Results Within GPi, we identified PAC between phase of β and amplitude of high frequency oscillations (200–300 Hz) and distinct β-low γ (40–80 Hz) PAC both modulated by contralateral movement. Resting β-low γ PAC, also present in dystonia patients, inversely correlated with severity of rigidity and bradykinesia (R = −0.44, P = 0.028). These findings were specific to the low β band, suggesting a differential role for the two β sub-bands. Conclusions PAC is present across distinct frequency bands within the GPi. Given the presence of low β-low γ PAC in dystonia and the inverse correlation with symptom severity, we propose that this PAC may be a normal pallidal signal. Significance This study provides new evidence on the pathophysiological contribution of local pallidal coupling and suggests similar and distinct patterns of coupling within GPi and STN in PD.
KW - Basal ganglia
KW - Deep brain stimulation
KW - Parkinson disease
KW - Phase-amplitude coupling
KW - β oscillations
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U2 - 10.1016/j.clinph.2017.08.001
DO - 10.1016/j.clinph.2017.08.001
M3 - Article
C2 - 28942154
AN - SCOPUS:85029714702
SN - 1388-2457
VL - 128
SP - 2165
EP - 2178
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 11
ER -