Palladium Hydride-Enabled Hydroalkenylation of Strained Molecules

Ziyan Zhang, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We report the first palladium hydride enabled hydroalkenylation of strained molecules. This new mild protocol proceeds via a regio- and chemoselective hydropalladation step, followed by a photoinduced radical alkyl Heck reaction. This methodology represents a new reactivity mode for strained molecules and opens new avenues for photoinduced palladium catalysis. The reaction is compatible with a wide range of functional groups and can be applied to complex structures, delivering a diverse array of highly valuable and modifiable alkenylated cyclobutanes and cyclopropanes. A hydroalkenylation/diastereoselective rearrangement cascade toward a cyclopentene scaffold has also been demonstrated.

Original languageEnglish (US)
Pages (from-to)20875-20883
Number of pages9
JournalJournal of the American Chemical Society
Issue number45
StatePublished - Nov 16 2022

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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