p53: The Janus of autophagy?

Beth Levine; John Abrams

doi:10.1038/ncb0608-637

p53: The Janus of autophagy?

Beth Levine, John Abrams

Research output: Contribution to journal › Article › peer-review

188 Scopus citations

Abstract

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

Original language	English (US)
Pages (from-to)	637-639
Number of pages	3
Journal	Nature cell biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1038/ncb0608-637
State	Published - Jun 2008

ASJC Scopus subject areas

Cell Biology

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title = "p53: The Janus of autophagy?",

abstract = "The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.",

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AU - Abrams, John

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p53: The Janus of autophagy?

Abstract

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