@article{b7dc6a9b35884eb9b8a941345ea712d2,
title = "P53 ancestry: Gazing through an evolutionary lens",
abstract = "Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?",
author = "Lu, {Wan Jin} and Amatruda, {James F.} and Abrams, {John M.}",
note = "Funding Information: W.L. and J.M.A. are supported by R01 grants from the National Institute of General Medical Sciences and the National Institute of Alcohol Abuse and Alcoholism. J.F.A. is supported by R01 from the National Cancer Institute. We are grateful to A. Diehl for artwork preparation. Funding Information: We wish to thank the thousands of researchers whose outstanding work over the past 30 years has made p53 research so exciting. We apologize to all our colleagues whose important contributions could not be cited owing to lack of space. Work in the authors{\textquoteright} laboratories is supported by grant R37 CA40099 from the National Cancer Institute, USA, a Center of Excellence grant from the Flight Attendant Medical Research Institute, USA, grants from the European Commission (Mutp53, FP6 Contract 502983 and OncomiRs, FP7 Contract 201102) and the Robert Bosch Foundation, Germany, (to M.O.), grant PO1 CA 87497 from the US National Institutes of Health, grant W81XWH-06-1-0514 from the Department of Defense, USA, grants from the Breast Cancer Research Foundation, USA, (to A.J.L.) and general support from the Simons Center for Systems Biology at the Institute for Advanced Study from the Simons Foundation, USA.",
year = "2009",
month = oct,
doi = "10.1038/nrc2732",
language = "English (US)",
volume = "9",
pages = "758--762",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "10",
}