p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

David M. Holtzman; Yiwen Li; Luis F. Parada; Stephen Kinsman; Chu Kuang Chen; Janice S. Valletta; Jie Zhou; Joseph B. Long; William C. Mobley

doi:10.1016/0896-6273(92)90184-F

p140^trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

David M. Holtzman, Yiwen Li, Luis F. Parada, Stephen Kinsman, Chu Kuang Chen, Janice S. Valletta, Jie Zhou, Joseph B. Long, William C. Mobley

Developmental Biology

Research output: Contribution to journal › Article › peer-review

376 Scopus citations

Abstract

Nerve growth factor (NGF) appears to act as a neurotrophic factor for basal forebrain and caudate-putamen cholinergic neurons. The mechanism by which NGF transduces its signal in these neurons is yet to be defined. Recent data indicate that the product of the trk gene, p140^trk is a critical component of the NGF receptor. Herein, we show that p140^trk mRNA is highly restricted in its distribution in the adult rat forebrain, that it is present in cholinergic neurons, and that most if not all cholinergic neurons contain p140^trk mRNA. Furthermore, induction of trk expression by NGF suggests that neurotrophin-mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors.

Original language	English (US)
Pages (from-to)	465-478
Number of pages	14
Journal	Neuron
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0896-6273(92)90184-F
State	Published - Sep 1992

ASJC Scopus subject areas

General Neuroscience

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10.1016/0896-6273(92)90184-F

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title = "p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF",

abstract = "Nerve growth factor (NGF) appears to act as a neurotrophic factor for basal forebrain and caudate-putamen cholinergic neurons. The mechanism by which NGF transduces its signal in these neurons is yet to be defined. Recent data indicate that the product of the trk gene, p140trk is a critical component of the NGF receptor. Herein, we show that p140trk mRNA is highly restricted in its distribution in the adult rat forebrain, that it is present in cholinergic neurons, and that most if not all cholinergic neurons contain p140trk mRNA. Furthermore, induction of trk expression by NGF suggests that neurotrophin-mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors.",

author = "Holtzman, {David M.} and Yiwen Li and Parada, {Luis F.} and Stephen Kinsman and Chen, {Chu Kuang} and Valletta, {Janice S.} and Jie Zhou and Long, {Joseph B.} and Mobley, {William C.}",

note = "Funding Information: W. C. M. extends his thanks to Dr. Samuel Ajl of the March of Dimes for his support of research on NGF in the CNS and dedicates this manuscript to him. The authors wish to thank Mark Grimes, Barbara Chapman, and David Kaplan for helpful comments and Dianne Esson for administrative assistance. This work was supported by National Institutes of Health grants AGOO445-02 (D. M. H.), NS24054, AG10672, and AGO8938 (W. C. M.) and the March of Dimes (W. C. M.). D. M. H. is also supported by an American Academy of Neurology Research Fellowship Award.",

year = "1992",

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doi = "10.1016/0896-6273(92)90184-F",

language = "English (US)",

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T1 - p140trk mRNA marks NGF-responsive forebrain neurons

T2 - Evidence that trk gene expression is induced by NGF

AU - Holtzman, David M.

AU - Li, Yiwen

AU - Parada, Luis F.

AU - Kinsman, Stephen

AU - Chen, Chu Kuang

AU - Valletta, Janice S.

AU - Zhou, Jie

AU - Long, Joseph B.

AU - Mobley, William C.

N1 - Funding Information: W. C. M. extends his thanks to Dr. Samuel Ajl of the March of Dimes for his support of research on NGF in the CNS and dedicates this manuscript to him. The authors wish to thank Mark Grimes, Barbara Chapman, and David Kaplan for helpful comments and Dianne Esson for administrative assistance. This work was supported by National Institutes of Health grants AGOO445-02 (D. M. H.), NS24054, AG10672, and AGO8938 (W. C. M.) and the March of Dimes (W. C. M.). D. M. H. is also supported by an American Academy of Neurology Research Fellowship Award.

PY - 1992/9

Y1 - 1992/9

N2 - Nerve growth factor (NGF) appears to act as a neurotrophic factor for basal forebrain and caudate-putamen cholinergic neurons. The mechanism by which NGF transduces its signal in these neurons is yet to be defined. Recent data indicate that the product of the trk gene, p140trk is a critical component of the NGF receptor. Herein, we show that p140trk mRNA is highly restricted in its distribution in the adult rat forebrain, that it is present in cholinergic neurons, and that most if not all cholinergic neurons contain p140trk mRNA. Furthermore, induction of trk expression by NGF suggests that neurotrophin-mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors.

AB - Nerve growth factor (NGF) appears to act as a neurotrophic factor for basal forebrain and caudate-putamen cholinergic neurons. The mechanism by which NGF transduces its signal in these neurons is yet to be defined. Recent data indicate that the product of the trk gene, p140trk is a critical component of the NGF receptor. Herein, we show that p140trk mRNA is highly restricted in its distribution in the adult rat forebrain, that it is present in cholinergic neurons, and that most if not all cholinergic neurons contain p140trk mRNA. Furthermore, induction of trk expression by NGF suggests that neurotrophin-mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors.

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p140^trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

Abstract

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