TY - GEN
T1 - Oximetry of Tissue Vasculature with Near Infrared Spectroscopy
T2 - Conference on Lasers and Electro-Optics, CLEO 2003
AU - Liu, Hanli
AU - Gu, Yueqing
AU - Kim, Jae G.
AU - Mason, Ralph P.
N1 - Funding Information:
This work was supported in part by the Department of Defense Breast Cancer Research grants BC990287 (HL) and BC000833 (YG), and NIH RO1 CA79515 (RPM).
Publisher Copyright:
© 2003 OSA/CLEO 2003, © 2002 Optical Society of America.
PY - 2003
Y1 - 2003
N2 - Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.
AB - Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.
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M3 - Conference contribution
AN - SCOPUS:85080104755
T3 - Optics InfoBase Conference Papers
BT - Conference on Lasers and Electro-Optics, CLEO 2003
PB - Optica Publishing Group (formerly OSA)
Y2 - 1 June 2003 through 6 June 2003
ER -