Oximetry of tissue vasculature with near infrared spectroscopy: Application to tumors

Hanli Liu, Yueqing Gu, Jae G. Kim, Ralph P. Mason

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.

Original languageEnglish (US)
Title of host publicationOSA Trends in Optics and Photonics Series
PublisherOptical Society of American (OSA)
Number of pages4
StatePublished - 2003
EventConference on Lasers and Electro-Optics (CLEO); Postconference Digest - Baltimore, MD, United States
Duration: Jun 1 2003Jun 6 2003


OtherConference on Lasers and Electro-Optics (CLEO); Postconference Digest
Country/TerritoryUnited States
CityBaltimore, MD

ASJC Scopus subject areas

  • General Engineering


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