Abstract
Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.
| Original language | English (US) |
|---|---|
| Title of host publication | OSA Trends in Optics and Photonics Series |
| Publisher | Optical Society of American (OSA) |
| Pages | 198-201 |
| Number of pages | 4 |
| Volume | 88 |
| State | Published - 2003 |
| Event | Conference on Lasers and Electro-Optics (CLEO); Postconference Digest - Baltimore, MD, United States Duration: Jun 1 2003 → Jun 6 2003 |
Other
| Other | Conference on Lasers and Electro-Optics (CLEO); Postconference Digest |
|---|---|
| Country/Territory | United States |
| City | Baltimore, MD |
| Period | 6/1/03 → 6/6/03 |
ASJC Scopus subject areas
- General Engineering