Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

Earth & Environmental Sciences

• antagonism 76%
• nucleic acid 71%
• pathogen 54%
• pattern recognition 44%
• sensor 40%
• inhibitor 36%
• primate 31%
• gene 22%
• defense 18%
• arms race 15%
• immune response 13%
• immune system 12%
• analysis 10%
• RNA 10%
• virus 9%
• family 7%
• organism 6%
• history 5%

Medicine & Life Sciences

• GMP synthase (glutamine-hydrolyzing) 100%
• cyclic guanosine monophosphate-adenosine monophosphate 89%
• 2',5'-oligoadenylate 88%
• Nucleic Acids 57%
• Pattern Recognition Receptors 37%
• Primates 20%
• Gene Duplication 9%
• Double-Stranded RNA 8%
• Innate Immunity 6%
• Nucleotides 5%
• Genes 5%
• Immune System 5%
• Viruses 4%

Agriculture & Biology

• cyclic GMP 71%
• antagonism 61%
• nucleic acids 54%
• pathogens 34%
• receptors 22%
• Primates 22%
• innate immunity 16%
• double-stranded RNA 9%
• gene duplication 9%
• nucleotides 5%
• genes 5%
• viruses 5%
• organisms 4%