TY - JOUR
T1 - Overlapping biomarkers, pathways, processes and syndromes in lymphatic development, growth and neoplasia
AU - Witte, Marlys H.
AU - Dellinger, Michael T.
AU - Papendieck, Cristobal M.
AU - Boccardo, Francesco
N1 - Funding Information:
Acknowledgments MTD received funding from a Department of Defense Breast Cancer Research Postdoctoral fellowship (W81XWH-10-1-0052). MHW, CP, FB thank the International Society of Lymphology whose practitioners and basic scientists around the world care for and explore the basis for these rare and more common clinical disorders.
PY - 2012/10
Y1 - 2012/10
N2 - Recent discoveries in molecular lymphology, developmental biology, and tumor biology in the context of long-standing concepts and observations on development, growth, and neoplasia implicate overlapping pathways, processes, and clinical manifestations in developmental disorders and cancer metastasis. Highlighted in this review are some of what is known (and speculated) about the genes, proteins, and signaling pathways and processes involved in lymphatic/blood vascular development in comparison to those involved in cancer progression and spread. Clues and conundra from clinical disorders that mix these processes and mute them, including embryonic rests, multicentric nests of displaced cells, uncontrolled/invasive "benign" proliferation and lymphogenous/hematogenous "spread", represent a fine line between normal development and growth, dysplasia, benign and malignant neoplasia, and "metastasis". Improved understanding of these normal and pathologic processes and their underlying pathomechanisms, e.g., stem cell origin and bidirectional epithelial-mesenchymal transition, could lead to more successful approaches in classification, treatment, and even prevention of cancer and a whole host of other diseases.
AB - Recent discoveries in molecular lymphology, developmental biology, and tumor biology in the context of long-standing concepts and observations on development, growth, and neoplasia implicate overlapping pathways, processes, and clinical manifestations in developmental disorders and cancer metastasis. Highlighted in this review are some of what is known (and speculated) about the genes, proteins, and signaling pathways and processes involved in lymphatic/blood vascular development in comparison to those involved in cancer progression and spread. Clues and conundra from clinical disorders that mix these processes and mute them, including embryonic rests, multicentric nests of displaced cells, uncontrolled/invasive "benign" proliferation and lymphogenous/hematogenous "spread", represent a fine line between normal development and growth, dysplasia, benign and malignant neoplasia, and "metastasis". Improved understanding of these normal and pathologic processes and their underlying pathomechanisms, e.g., stem cell origin and bidirectional epithelial-mesenchymal transition, could lead to more successful approaches in classification, treatment, and even prevention of cancer and a whole host of other diseases.
KW - Biomarkers
KW - Cancer metastasis
KW - EMT-MET
KW - Lymphatic development
KW - Lymphogenous dissemination
KW - Vascular neoplasia
UR - http://www.scopus.com/inward/record.url?scp=84868215136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868215136&partnerID=8YFLogxK
U2 - 10.1007/s10585-012-9493-1
DO - 10.1007/s10585-012-9493-1
M3 - Article
C2 - 22798218
AN - SCOPUS:84868215136
SN - 0262-0898
VL - 29
SP - 707
EP - 727
JO - Clinical and Experimental Metastasis
JF - Clinical and Experimental Metastasis
IS - 7
ER -