Overdiagnosis: An Understudied Issue in Hepatocellular Carcinoma Surveillance

Nicole E. Rich, Neehar D. Parikh, Amit G. Singal

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Overdiagnosis, the detection of clinically insignificant disease that would not otherwise impact the patient's lifespan, is a phenomenon that has been described in several solid tumors, such as prostate, breast, thyroid, and lung cancers. Population-based efforts to reduce hepatocellular carcinoma (HCC) mortality in cirrhosis patients by screening and early detection may result in the overdiagnosis of HCC. One of the harms of overdiagnosis is subsequent overtreatment, which can result in increased costs, as well as physical side effects, psychological harms, and poorer quality of life. In this review, the authors explore the potential for overdiagnosis in HCC.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalSeminars in liver disease
Issue number4
StatePublished - Nov 1 2017


  • HCC
  • harms
  • overdiagnosis
  • overtreatment
  • screening
  • surveillance

ASJC Scopus subject areas

  • Hepatology


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