TY - JOUR
T1 - Outcomes of infants with hypoxic ischemic encephalopathy and persistent pulmonary hypertension of the newborn
T2 - results from three NICHD studies
AU - for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network
AU - Agarwal, Prashant
AU - Shankaran, Seetha
AU - Laptook, Abbot R.
AU - Chowdhury, Dhuly
AU - Lakshminrusimha, Satyan
AU - Bonifacio, Sonia Lomeli
AU - Natarajan, Girija
AU - Chawla, Sanjay
AU - Keszler, Martin
AU - Heyne, Roy J.
AU - Ambalavanan, Namasivayam
AU - Walsh, Michele C.
AU - Das, Abhik
AU - Van Meurs, Krisa P.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Objective: To determine the association of persistent pulmonary hypertension of the newborn (PPHN) with death or disability among infants with moderate or severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. Methods: We compared infants with and without PPHN enrolled in the hypothermia arm from three randomized controlled trials (RCTs): Induced Hypothermia trial, “usual care” arm of Optimizing Cooling trial, and Late Hypothermia trial. Primary outcome was death or disability at 18–22 months adjusted for severity of HIE, center, and RCT. Results: Among 280 infants, 67 (24%) were diagnosed with PPHN. Among infants with and without PPHN, death or disability was 47% vs. 29% (adjusted OR: 1.65, 0.86–3.14) and death was 26% vs. 12% (adjusted OR: 2.04, 0.92–4.53), respectively. Conclusions: PPHN in infants with moderate or severe HIE was not associated with a statistically significant increase in primary outcome. These results should be interpreted with caution given the limited sample size.
AB - Objective: To determine the association of persistent pulmonary hypertension of the newborn (PPHN) with death or disability among infants with moderate or severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. Methods: We compared infants with and without PPHN enrolled in the hypothermia arm from three randomized controlled trials (RCTs): Induced Hypothermia trial, “usual care” arm of Optimizing Cooling trial, and Late Hypothermia trial. Primary outcome was death or disability at 18–22 months adjusted for severity of HIE, center, and RCT. Results: Among 280 infants, 67 (24%) were diagnosed with PPHN. Among infants with and without PPHN, death or disability was 47% vs. 29% (adjusted OR: 1.65, 0.86–3.14) and death was 26% vs. 12% (adjusted OR: 2.04, 0.92–4.53), respectively. Conclusions: PPHN in infants with moderate or severe HIE was not associated with a statistically significant increase in primary outcome. These results should be interpreted with caution given the limited sample size.
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U2 - 10.1038/s41372-020-00905-7
DO - 10.1038/s41372-020-00905-7
M3 - Article
C2 - 33402707
AN - SCOPUS:85098952589
SN - 0743-8346
VL - 41
SP - 502
EP - 511
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 3
ER -