Outcome predictors and spectrum of treatment eligibility with prospective protocolized management of intracerebral hemorrhage

Jennifer Jaffe, Lora Alkhawam, Hongyan Du, Kristen Tobin, Judith O'Leary, Glen Pollock, H. Hunt Batjer, Issam A. Awad

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


OBJECTIVE: Risk predictors, spectrum of treatment eligibility, and range of expected outcomes have not been validated in consecutive series including all cases of intracerebral hemorrhage (ICH) subjected to a prospective management protocol based on current guidelines. METHODS: Eighty-six cases of ICH were prospectively identified in conjunction with screening for a clinical trial during an 18-month period. All patients were subjected to protocolized management based on published "best practice" guidelines for ICH. Medical records were reviewed by trained researchers, and outcomes were assessed at various time points including latest follow-up (range, 0-24 months; mean, 3.97 months). Initial assessment parameters, treatment eligibility, and outcomes were based on standardized criteria. RESULTS: In accordance with past literature, mortality and functional outcomes were significantly worse in older patients, those with a larger ICH volume, and worse Glasgow Coma Scale scores, in univariate and multivariate models. The presence and severity of associated intraventricular hemorrhage also correlated with mortality and outcome. Significantly lower mortality (P = 0.024) and better functional outcomes (P = 0.018) were achieved at 30 days in patients with an ICH volume of less than 30 cm3 in this series than in previously published community-based historical controls without protocolized care. A tight correspondence between treatment eligibility and treatment administered was found. CONCLUSION: Previous estimates of poorer outcome in patients with ICH might not apply to contemporary management protocols, especially in patients with a smaller ICH volume. Outcome ranges in various risk categories and modeling of treatment eligibility will help project more realistic prognostication and assist with the design of future trials.

Original languageEnglish (US)
Pages (from-to)436-445
Number of pages10
Issue number3
StatePublished - Mar 2009


  • Intracerebral hemorrhage
  • Outcome prediction
  • Treatment

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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