Ototoxicity of Vasocidin Drops Applied to the Chinchilla Middle Ear

O. E. Brown, C. G. Wright, M. Masaki, W. L. Meyerhoff

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Some widely used ototopical preparations are potentially toxic to the middle and inner ear. Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic side effects in the treatment of otorrhea. Vasocidin was introduced into the bullae of nine chinchillas to investigate the effects on the middle and inner ear. The organ of Corti and stria vascularis were found to be entirely normal in 17 of the 18 temporal bones studied. Changes observed in the middle ears at one week included inflammation, hemorrhage, and effusion. Examination of specimens at four weeks revealed resolution of most of the inflammatory changes. The results of this experimental study indicate that Vasocidin causes reversible middle ear inflammation with little or no toxic effect on inner ear structures.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalArchives of Otolaryngology--Head and Neck Surgery
Issue number1
StatePublished - Jan 1988

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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