Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Shunsuke Yamada; Masatomo Taniguchi; Masanori Tokumoto; Kazuhiko Tsuruya; Mitsuo Iida

doi:10.1093/ndtplus/sfp010

Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Mitsuo Iida

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the 'left knee' occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.

Original language	English (US)
Pages (from-to)	155-157
Number of pages	3
Journal	NDT Plus
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/ndtplus/sfp010
State	Published - Apr 2009

Keywords

Calcitonin receptor
Multi-nucleated giant cell
Osteoclast
Tumoral calcinosis

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndtplus/sfp010

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abstract = "A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the 'left knee' occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.",

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AU - Tsuruya, Kazuhiko

AU - Iida, Mitsuo

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Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Abstract

Keywords

ASJC Scopus subject areas

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