Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease

Arenda H E A van Beek, Joep Lagro, Marcel G M Olde-Rikkert, Rong Zhang, Jurgen A H R Claassen

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


In Alzheimer's disease (AD) cerebrovascular function is at risk. Transcranial Doppler, near-infrared spectroscopy, and photoplethysmography are noninvasive methods to continuously measure changes in cerebral blood flow velocity (CBFV), cerebral cortical oxygenated hemoglobin (O2Hb), and blood pressure (BP). In 21 patients with mild to moderate AD and 20 age-matched controls, we investigated how oscillations in cerebral blood flow velocity (CBFV) and O2Hb are associated with spontaneous and induced oscillations in blood pressure (BP) at the very low (VLF = 0.05 Hz) and low frequencies (LF = 0.1 Hz). We applied spectral and transfer function analysis to quantify dynamic cerebral autoregulation and brain tissue oxygenation. In AD, cerebrovascular resistance was substantially higher (34%, AD vs. control: δ = 0.69 (0.25) mm Hg/cm/second, p = 0.012) and the transmission of very low frequency (VLF) cerebral blood flow (CBF) oscillations into O2Hb differed, with increased phase lag and gain (δ phase 0.32 [0.15] rad; δ gain 0.049 [0.014] μmol/cm/second, p both < 0.05). The altered transfer of CBF to cortical oxygenation in AD indicates that properties of the cerebral microvasculature are changed in this disease.

Original languageEnglish (US)
Pages (from-to)428.e21-428.e31
JournalNeurobiology of Aging
Issue number2
StatePublished - Feb 2012


  • Alzheimer's disease
  • Brain tissue oxygenation
  • Cerebral autoregulation
  • Cerebrovascular disease
  • Near infrared spectroscopy
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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