Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

Research output: Contribution to journalShort surveypeer-review

331 Scopus citations


With the recent characterizations of several nuclear orphan receptors, an emerging theme has developed placing these receptors as master regulators of lipid metabolism. The identification of the oxysterol receptors (LXRs) and a bile acid receptor (FXR) has opened up new and exciting fields of research in cholesterol and bile acid metabolism. Understanding the physiological pathways that these receptors regulate and designing pharmaceutical drugs for these receptors may provide alternative treatments for cholesterol and bile acid disorders.

Original languageEnglish (US)
Pages (from-to)37735-37738
Number of pages4
JournalJournal of Biological Chemistry
Issue number41
StatePublished - Oct 12 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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