@article{c5f5812e075b4edabe9581bd142917a1,
title = "Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act",
abstract = "Organs from deceased donors with suspected false-positive HIV screening tests were generally discarded due to the chance that the test was truly positive. However, the HIV Organ Policy Equity (HOPE) Act now facilitates use of such organs for transplantation to HIV-infected (HIV+) individuals. In the HOPE in Action trial, donors without a known HIV infection who unexpectedly tested positive for anti-HIV antibody (Ab) or HIV nucleic acid test (NAT) were classified as suspected false-positive donors. Between March 2016 and March 2018, 10 suspected false-positive donors had organs recovered for transplant for 21 HIV + recipients (14 single-kidney, 1 double-kidney, 5 liver, 1 simultaneous liver-kidney). Median donor age was 24 years; cause of death was trauma (n = 5), stroke (n = 4), and anoxia (n = 1); three donors were labeled Public Health Service increased infectious risk. Median kidney donor profile index was 30.5 (IQR 22-58). Eight donors were HIV Ab+/NAT-; two were HIV Ab-/NAT+. All 10 suspected false-positive donors were confirmed to be HIV-noninfected. Given the false-positive rates of approved assays used to screen > 20 000 deceased donors annually, we estimate 50-100 HIV false-positive donors per year. Organ transplantation from suspected HIV false-positive donors is an unexpected benefit of the HOPE Act that provides another novel organ source.",
keywords = "acquired immunodeficiency syndrome (AIDS), clinical research, clinical trial, donors and donation: donor evaluation, infection and infectious agents—viral: human immunodeficiency virus (HIV), infectious disease, law, legislation, organ allocation, organ procurement organization, organ transplantation in general, practice",
author = "Durand, {Christine M.} and Halpern, {Samantha E.} and Bowring, {Mary G.} and Bismut, {Gilad A.} and Kusemiju, {Oyinkansola T.} and Brianna Doby and Fernandez, {Reinaldo E.} and Kirby, {Charles S.} and Darin Ostrander and Stock, {Peter G.} and Shikha Mehta and Turgeon, {Nicole A.} and David Wojciechowski and Shirish Huprikar and Sander Florman and Shane Ottmann and Desai, {Niraj M.} and Andrew Cameron and Massie, {Allan B.} and Tobian, {Aaron A.R.} and Redd, {Andrew D.} and Segev, {Dorry L.}",
note = "Funding Information: This work was supported by grant numbers K24DK101828 and K01DK101677 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), 1R01AI120938-01A1 and U01AI134591 from the National Institute of Allergy and Infectious Diseases (NIAID) and K23CA177321 from the National Cancer Institute (NCI), and in part by the Division of Intramural Research, NIAID, National Institutes of Health. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Funding Information: This work was supported by grant numbers K24DK101828 and K01DK101677 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), 1R01AI120938‐01A1 and U01AI134591 from the National Institute of Allergy and Infectious Diseases (NIAID) and K23CA177321 from the National Cancer Institute (NCI), and in part by the Division of Intramural Research, NIAID, National Institutes of Health. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Publisher Copyright: {\textcopyright} 2018 The American Society of Transplantation and the American Society of Transplant Surgeons",
year = "2018",
month = oct,
doi = "10.1111/ajt.14993",
language = "English (US)",
volume = "18",
pages = "2579--2586",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "10",
}