Organocopper-mediated two-component S N2'-substitution cascade towards N-fused heterocycles

D. Chernyak, V. Gevorgyan

Research output: Contribution to journalArticlepeer-review


Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an S N2'-substitution followed by a consequent cycloisomerization step.

Original languageEnglish (US)
Pages (from-to)1816-1827
Number of pages12
JournalKhimiya Geterotsiklicheskikh Soedinenii
Issue number12
StatePublished - Dec 1 2011
Externally publishedYes


  • Allenes
  • Cycloisomerization
  • Indolizines
  • Propargyl mesylates
  • Synthetic methods

ASJC Scopus subject areas

  • Organic Chemistry


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