TY - JOUR
T1 - Organelle communication
T2 - Signaling crossroads between homeostasis and disease
AU - Bravo-Sagua, Roberto
AU - Torrealba, Natalia
AU - Paredes, Felipe
AU - Morales, Pablo E.
AU - Pennanen, Christian
AU - López-Crisosto, Camila
AU - Troncoso, Rodrigo
AU - Criollo, Alfredo
AU - Chiong, Mario
AU - Hill, Joseph A
AU - Simmen, Thomas
AU - Quest, Andrew F.
AU - Lavandero, Sergio
N1 - Funding Information:
This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.
PY - 2014/5
Y1 - 2014/5
N2 - Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.
AB - Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.
KW - Calcium signaling
KW - Endoplasmic reticulum
KW - Mitochondria
KW - Organelles
UR - http://www.scopus.com/inward/record.url?scp=84896284232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896284232&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2014.01.019
DO - 10.1016/j.biocel.2014.01.019
M3 - Short survey
C2 - 24534274
AN - SCOPUS:84896284232
SN - 1357-2725
VL - 50
SP - 55
EP - 59
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 1
ER -