TY - JOUR
T1 - Orexins and orexin receptors
T2 - A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
AU - Sakurai, Takeshi
AU - Amemiya, Akira
AU - Ishii, Makoto
AU - Matsuzaki, Ichiyo
AU - Chemelli, Richard M.
AU - Tanaka, Hirokazu
AU - Williams, S. Clay
AU - Richardson, James A
AU - Kozlowski, Gerald P.
AU - Wilson, Shelagh
AU - Arch, Jonathan R S
AU - Buckingham, Robin E.
AU - Haynes, Andrea C.
AU - Carr, Steven A.
AU - Annan, Roland S.
AU - McNulty, Dean E.
AU - Liu, Wu Schyong
AU - Terrett, Jonathan A.
AU - Elshourbagy, Nabil A.
AU - Bergsma, Derk J.
AU - Yanagisawa, Masashi
N1 - Funding Information:
We thank Katsutoshi Goto for discussion, Tadahiro Nambu for technical assistance in immunohistochemistry, and Mike Brown and Joe Goldstein for critically reading the manuscript. We also thank the following scientists at SmithKline Beecham for their various contributions: Neil Upton, Christine Debouck, Catherine Ellis, Ganesh Sathe, Michael Huddleston, Jeff Stadel, John Martin, Lily Zhang, Paul Lysko, and Mary Brawner. M. Y. is an Investigator and T. S. and A. A. are Associates of the Howard Hughes Medical Institute. R. M. C. is an NIH fellow of the Pediatric Scientist Development Program. M. I. is a Summer Undergraduate Research Fellow of the University of Texas Southwestern Medical Center. This work was supported in part by research grants from the Perot Family Foundation.
PY - 1998/2/20
Y1 - 1998/2/20
N2 - The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.
AB - The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.
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U2 - 10.1016/S0092-8674(00)80949-6
DO - 10.1016/S0092-8674(00)80949-6
M3 - Article
C2 - 9491897
AN - SCOPUS:20244380014
SN - 0092-8674
VL - 92
SP - 573
EP - 585
JO - Cell
JF - Cell
IS - 4
ER -