Optimality in evolution: New insights from synthetic biology

Marjon G J de Vos, Frank J. Poelwijk, Sander J. Tans

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Whether organisms evolve to perform tasks optimally has intrigued biologists since Lamarck and Darwin. Optimality models have been used to study diverse properties such as shape, locomotion, and behavior. However, without access to the genetic underpinnings or the ability to manipulate biological functions, it has been difficult to understand an organism's intrinsic potential and limitations. Now, novel experiments are overcoming these technical obstacles and have begun to test optimality in more quantitative terms. With the use of simple model systems, genetic engineering, and mathematical modeling, one can independently quantify the prevailing selective pressures and optimal phenotypes. These studies have given an exciting view into the evolutionary potential and constraints of biological systems, and hold the promise to further test the limits of predicting future evolutionary change.

Original languageEnglish (US)
Pages (from-to)797-802
Number of pages6
JournalCurrent Opinion in Biotechnology
Issue number4
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


Dive into the research topics of 'Optimality in evolution: New insights from synthetic biology'. Together they form a unique fingerprint.

Cite this