Optimal Tissue Sampling: The Pathologist's Perspective

Richard H. Lash, Shari L. Taylor, Robert M. Genta

Research output: Chapter in Book/Report/Conference proceedingChapter


The pathologist's ability to correctly interpret a biopsy from the gastrointestinal tract, liver, or pancreas hinges on several factors, including the quality and provenance of the specimen, and the extent and quality of the clinical and endoscopic information provided. This chapter reviews, from the pathologists' perspective, the optimal biopsy methods for each organ, emphasizing the specific sampling requirements to maximize the diagnostic yield of mucosal and liver biopsies in a variety of clinical conditions.

Original languageEnglish (US)
Title of host publicationTextbook of Clinical Gastroenterology and Hepatology
Subtitle of host publicationSecond Edition
Number of pages8
ISBN (Print)1405191821, 9781405191821
StatePublished - Apr 16 2012


  • Colon biopsy
  • Duodenal biopsy
  • Esophageal biopsy
  • Gastric biopsy
  • Histopathology
  • Liver biopsy
  • Mucosal biopsy
  • Pathology
  • Small intestinal biopsy
  • Special stains
  • Tissue sampling

ASJC Scopus subject areas

  • Medicine(all)


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