Optical coherence tomography in multiple sclerosis

Elliot Frohman; Fiona Costello; Robert Zivadinov; Olaf Stuve; Amy Conger; Heather Winslow; Anand Trip; Teresa Frohman; Laura Balcer

doi:10.1016/S1474-4422(06)70573-7

Optical coherence tomography in multiple sclerosis

Elliot Frohman, Fiona Costello, Robert Zivadinov, Olaf Stuve, Amy Conger, Heather Winslow, Anand Trip, Teresa Frohman, Laura Balcer

Research output: Contribution to journal › Review article › peer-review

148 Scopus citations

Abstract

We do not have currently satisfactory clinical and anatomical correlates to gauge disability in multiple sclerosis. Structural biomarkers (such as MRI) are hindered because they cannot precisely segregate demyelination from axonal elements of tissue injury within the CNS. Axonal degeneration in multiple sclerosis is related to irreversible disability, which suggests that the confirmation of neuroprotective strategies needs highly quantifiable measures of axon loss that can be correlated with reliable measures of physiological function. The coupling of quantifiable measures of visual function with ocular imaging techniques, such as optical coherence tomography, enables us to begin to understand how structural changes in the visual system influence function in patients with multiple sclerosis. In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis.

Original language	English (US)
Pages (from-to)	853-863
Number of pages	11
Journal	Lancet Neurology
Volume	5
Issue number	10
DOIs	https://doi.org/10.1016/S1474-4422(06)70573-7
State	Published - Oct 2006

ASJC Scopus subject areas

Clinical Neurology

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title = "Optical coherence tomography in multiple sclerosis",

abstract = "We do not have currently satisfactory clinical and anatomical correlates to gauge disability in multiple sclerosis. Structural biomarkers (such as MRI) are hindered because they cannot precisely segregate demyelination from axonal elements of tissue injury within the CNS. Axonal degeneration in multiple sclerosis is related to irreversible disability, which suggests that the confirmation of neuroprotective strategies needs highly quantifiable measures of axon loss that can be correlated with reliable measures of physiological function. The coupling of quantifiable measures of visual function with ocular imaging techniques, such as optical coherence tomography, enables us to begin to understand how structural changes in the visual system influence function in patients with multiple sclerosis. In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis.",

author = "Elliot Frohman and Fiona Costello and Robert Zivadinov and Olaf Stuve and Amy Conger and Heather Winslow and Anand Trip and Teresa Frohman and Laura Balcer",

note = "Funding Information: Supported by The Lone Star Chapter of the National Multiple Sclerosis Society, the “Once Upon A Time”, the Cain/Denius Comprehensive Center for Mobility Research, the Irene Wadel and Robert Atha fund, the Kenney Marie Dixon Pickens fund, the Jean Ann and Steve Brock Fund for Medical Sciences, the Hawn Foundation (EMF), and Karen and Walter Levy. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

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doi = "10.1016/S1474-4422(06)70573-7",

language = "English (US)",

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T1 - Optical coherence tomography in multiple sclerosis

AU - Frohman, Elliot

AU - Costello, Fiona

AU - Zivadinov, Robert

AU - Stuve, Olaf

AU - Conger, Amy

AU - Winslow, Heather

AU - Trip, Anand

AU - Frohman, Teresa

AU - Balcer, Laura

N1 - Funding Information: Supported by The Lone Star Chapter of the National Multiple Sclerosis Society, the “Once Upon A Time”, the Cain/Denius Comprehensive Center for Mobility Research, the Irene Wadel and Robert Atha fund, the Kenney Marie Dixon Pickens fund, the Jean Ann and Steve Brock Fund for Medical Sciences, the Hawn Foundation (EMF), and Karen and Walter Levy. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/10

Y1 - 2006/10

N2 - We do not have currently satisfactory clinical and anatomical correlates to gauge disability in multiple sclerosis. Structural biomarkers (such as MRI) are hindered because they cannot precisely segregate demyelination from axonal elements of tissue injury within the CNS. Axonal degeneration in multiple sclerosis is related to irreversible disability, which suggests that the confirmation of neuroprotective strategies needs highly quantifiable measures of axon loss that can be correlated with reliable measures of physiological function. The coupling of quantifiable measures of visual function with ocular imaging techniques, such as optical coherence tomography, enables us to begin to understand how structural changes in the visual system influence function in patients with multiple sclerosis. In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis.

AB - We do not have currently satisfactory clinical and anatomical correlates to gauge disability in multiple sclerosis. Structural biomarkers (such as MRI) are hindered because they cannot precisely segregate demyelination from axonal elements of tissue injury within the CNS. Axonal degeneration in multiple sclerosis is related to irreversible disability, which suggests that the confirmation of neuroprotective strategies needs highly quantifiable measures of axon loss that can be correlated with reliable measures of physiological function. The coupling of quantifiable measures of visual function with ocular imaging techniques, such as optical coherence tomography, enables us to begin to understand how structural changes in the visual system influence function in patients with multiple sclerosis. In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis.

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SN - 1474-4422

VL - 5

SP - 853

EP - 863

JO - Lancet Neurology

JF - Lancet Neurology

IS - 10

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Optical coherence tomography in multiple sclerosis

Abstract

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