Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists

D. W. Self; W. J. Barnhart; D. A. Lehman; E. J. Nestler

doi:10.1126/science.271.5255.1586

Opposite modulation of cocaine-seeking behavior by D₁- and D₂-like dopamine receptor agonists

D. W. Self, W. J. Barnhart, D. A. Lehman, E. J. Nestler

Research output: Contribution to journal › Article › peer-review

444 Scopus citations

Abstract

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior, We found that this 'priming' effect was selectively induced by D₂-like, and not by D₁-like, dopamine receptor agonists in rats. Moreover, D₁-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D₂-like receptor agonists enhanced this behavior, These results demonstrate an important dissociation between D₁- and D₂-like receptor processes in cocaine-seeking behavior and support further evaluation of D₁-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

Original language	English (US)
Pages (from-to)	1586-1589
Number of pages	4
Journal	Science
Volume	271
Issue number	5255
DOIs	https://doi.org/10.1126/science.271.5255.1586
State	Published - Jan 1 1996

ASJC Scopus subject areas

General

Access to Document

10.1126/science.271.5255.1586

Cite this

@article{79f5adb181a74026b36ef6882fddc20b,

title = "Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists",

abstract = "Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior, We found that this 'priming' effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior, These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.",

author = "Self, {D. W.} and Barnhart, {W. J.} and Lehman, {D. A.} and Nestler, {E. J.}",

year = "1996",

month = jan,

day = "1",

doi = "10.1126/science.271.5255.1586",

language = "English (US)",

volume = "271",

pages = "1586--1589",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5255",

}

TY - JOUR

T1 - Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists

AU - Self, D. W.

AU - Barnhart, W. J.

AU - Lehman, D. A.

AU - Nestler, E. J.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior, We found that this 'priming' effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior, These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

AB - Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior, We found that this 'priming' effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior, These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

UR - http://www.scopus.com/inward/record.url?scp=0029870443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029870443&partnerID=8YFLogxK

U2 - 10.1126/science.271.5255.1586

DO - 10.1126/science.271.5255.1586

M3 - Article

C2 - 8599115

AN - SCOPUS:0029870443

SN - 0036-8075

VL - 271

SP - 1586

EP - 1589

JO - Science

JF - Science

IS - 5255

ER -

Opposite modulation of cocaine-seeking behavior by D₁- and D₂-like dopamine receptor agonists

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this