TY - JOUR
T1 - Opioid and benzodiazepine prescription among patients with cirrhosis compared to other forms of chronic disease
AU - Konerman, Monica A.
AU - Rogers, Mary
AU - Kenney, Brooke
AU - Singal, Amit G.
AU - Tapper, Elliot
AU - Sharma, Pratima
AU - Saini, Sameer
AU - Nallamothu, Brahmajee
AU - Waljee, Akbar
N1 - Funding Information:
AW's research is funded by a VA HSR&D CDA-2 Career Development Award (1IK2HX000775). AW and BN also receive support from Michigan Institute for Data Science (MIDAS) at the University of Michigan. AGS's research is funded by RO1MD12565 and R01 CA12008.
Funding Information:
Funding AW’s research is funded by a VA HSR&D CDA-2 Career Development Award (1IK2HX000775). AW and BN also receive support from Michigan Institute for Data Science (MIDAS) at the University of Michigan. AGS’s research is funded by RO1MD12565 and R01 CA12008. Disclaimer These funding sources did not have any role in the design, conduct, collection, management, analysis, interpretation, preparation, review or approval of the manuscript. This content is solely the responsibility of the authors and does not necessarily represent the official views of the healthcare centres, the NIH or the VA.
Publisher Copyright:
© 2019 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Objective Data on patterns and correlates of opioid and benzodiazepines prescriptions among patients with chronic conditions are limited. Given a diminished capacity for hepatic clearance, patients with cirrhosis represent a high risk group for use. The aim of this study was to characterise the patterns and correlates of prescription opioid, benzodiazepine and dual drug prescriptions among individuals with common chronic diseases. Design Analysis of Truven Marketscan database to evaluate individuals with drug coverage with cirrhosis (n=169,181), chronic hepatitis C without cirrhosis (n=210 191), congestive heart failure (n=766 840) or chronic obstructive pulmonary disease (n=1 438 798). Pharmacy files were examined for outpatient prescriptions. Results Patients with cirrhosis had a significantly higher prevalence of opioid prescriptions (37.1 per 100 person-years vs 24.3-26.0, p≤0.001) and benzodiazepine prescriptions (21.3 per 100 person-years vs 12.1-12.9, p<0.001). High dose opioid prescription (>90 daily oral morphine equivalents) (29.1% vs 14.4%, p<0.001) and dual opioid and benzodiazepine prescription (17.5% vs 9.6%-10.5 %, p<0.001) were also significantly more prevalent in cirrhosis. High dose opioid prescription was greater in men, individuals ages 40-59, in the Western USA, and among those with a mental health or substance abuse condition. Dual opioid and benzodiazepine prescription were highest among those with alcoholic cirrhosis and middle aged-adults. Conclusion Persons with cirrhosis have significantly higher rates of prescription opioid and benzodiazepine prescription compared to others with chronic diseases despite their high risk for adverse drug reactions. Demographics and mental health or substance abuse history can help identify high risk groups to target interventions.
AB - Objective Data on patterns and correlates of opioid and benzodiazepines prescriptions among patients with chronic conditions are limited. Given a diminished capacity for hepatic clearance, patients with cirrhosis represent a high risk group for use. The aim of this study was to characterise the patterns and correlates of prescription opioid, benzodiazepine and dual drug prescriptions among individuals with common chronic diseases. Design Analysis of Truven Marketscan database to evaluate individuals with drug coverage with cirrhosis (n=169,181), chronic hepatitis C without cirrhosis (n=210 191), congestive heart failure (n=766 840) or chronic obstructive pulmonary disease (n=1 438 798). Pharmacy files were examined for outpatient prescriptions. Results Patients with cirrhosis had a significantly higher prevalence of opioid prescriptions (37.1 per 100 person-years vs 24.3-26.0, p≤0.001) and benzodiazepine prescriptions (21.3 per 100 person-years vs 12.1-12.9, p<0.001). High dose opioid prescription (>90 daily oral morphine equivalents) (29.1% vs 14.4%, p<0.001) and dual opioid and benzodiazepine prescription (17.5% vs 9.6%-10.5 %, p<0.001) were also significantly more prevalent in cirrhosis. High dose opioid prescription was greater in men, individuals ages 40-59, in the Western USA, and among those with a mental health or substance abuse condition. Dual opioid and benzodiazepine prescription were highest among those with alcoholic cirrhosis and middle aged-adults. Conclusion Persons with cirrhosis have significantly higher rates of prescription opioid and benzodiazepine prescription compared to others with chronic diseases despite their high risk for adverse drug reactions. Demographics and mental health or substance abuse history can help identify high risk groups to target interventions.
KW - alcoholic liver disease
KW - chronic liver disease
KW - cirrhosis
KW - hcv
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U2 - 10.1136/bmjgast-2018-000271
DO - 10.1136/bmjgast-2018-000271
M3 - Article
C2 - 31139424
AN - SCOPUS:85064407791
SN - 2054-4774
VL - 6
JO - BMJ Open Gastroenterology
JF - BMJ Open Gastroenterology
IS - 1
M1 - e000271
ER -