TY - JOUR
T1 - Onset/offset characteristics and intubating conditions of rapacuronium
T2 - A comparison with rocuronium
AU - Zhou, T. J.
AU - White, P. F.
AU - Chiu, J. W.
AU - Joshi, G. P.
AU - Dullye, K. K.
AU - Duffy, L. L.
AU - Tongier, W. K.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - We compared onset and offset of action and tracheal intubating conditions after rapacuronium and rocuronium in 60 patients in a randomized, assessor-blinded study. Following induction of anaesthesia with propofol 2.5 mg kg-1, either rapacuronium 1.5 mg kg-1 (n=30) or rocuronium 0.6 mg kg-1 (n=30) was administered to facilitate tracheal intubation. Anaesthesia was maintained with either a propofol infusion (100 μg kg- 1 min-1) or sevoflurane (1% end-tidal) with 66% nitrous oxide (N2O), n=15 in each subgroup. Neuromuscular monitoring was performed using an electromyographic (EMG) device (Datex Relaxograph). The lag times (mean 42 (SD II) s and 44 (16) s), maximum block (99 (2)% and 98 (3)%) and intubating conditions at 60 s (good-to-excellent in 86% and 84% of patients) were similar for rapacuronium and rocuronium, respectively. The onset time of rapacuronium was shorter than rocuronium (87 (20) vs 141(65) s, P<0.001), and the degree of block at 60 s was greater (69 (26) vs 50 (27)%, P<0.05). Twenty-five per cent recovery was shorter with rapacuronium than rocuronium during propofol (15.0 (3.2) vs 39.1 (14.2) min, P<0.001) and sevoflurane (15.1 (4.2) vs 47.8 (19.0) min, P<0.001) anaesthesia. We conclude that rapacuronium 1.5 mg kg-1 had a more rapid onset, similar intubating conditions, and shorter recovery times than rocuronium 0.6 mg kg-1.
AB - We compared onset and offset of action and tracheal intubating conditions after rapacuronium and rocuronium in 60 patients in a randomized, assessor-blinded study. Following induction of anaesthesia with propofol 2.5 mg kg-1, either rapacuronium 1.5 mg kg-1 (n=30) or rocuronium 0.6 mg kg-1 (n=30) was administered to facilitate tracheal intubation. Anaesthesia was maintained with either a propofol infusion (100 μg kg- 1 min-1) or sevoflurane (1% end-tidal) with 66% nitrous oxide (N2O), n=15 in each subgroup. Neuromuscular monitoring was performed using an electromyographic (EMG) device (Datex Relaxograph). The lag times (mean 42 (SD II) s and 44 (16) s), maximum block (99 (2)% and 98 (3)%) and intubating conditions at 60 s (good-to-excellent in 86% and 84% of patients) were similar for rapacuronium and rocuronium, respectively. The onset time of rapacuronium was shorter than rocuronium (87 (20) vs 141(65) s, P<0.001), and the degree of block at 60 s was greater (69 (26) vs 50 (27)%, P<0.05). Twenty-five per cent recovery was shorter with rapacuronium than rocuronium during propofol (15.0 (3.2) vs 39.1 (14.2) min, P<0.001) and sevoflurane (15.1 (4.2) vs 47.8 (19.0) min, P<0.001) anaesthesia. We conclude that rapacuronium 1.5 mg kg-1 had a more rapid onset, similar intubating conditions, and shorter recovery times than rocuronium 0.6 mg kg-1.
KW - Anaesthetics i.v., propofol
KW - Anaesthetics volatile, sevoflurane
KW - Intubation, tracheal
KW - Neuromuscular block, rapacuronium
KW - Neuromuscular block, rocuronium
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U2 - 10.1093/bja/85.2.246
DO - 10.1093/bja/85.2.246
M3 - Article
C2 - 10992833
AN - SCOPUS:0033868076
SN - 0007-0912
VL - 85
SP - 246
EP - 250
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 2
ER -