A one-pot cascade synthesis of perfluoroaryl oxiranes 2 by the arylative epoxidation of enolizable ketones 1 with bromopentafluorobenzene (PFPBr) and derivatives (3) is reported. PFPBr is utilized as an equivalent of Br + and PFP - in this highly efficient, easily scaled-up, diastereoselective epoxidation reaction, which produces synthetically useful polyfluoroaryl oxiranes.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Jan 27 2012|
- cascade transformations
- perfluorinated compounds
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