Oncometabolites and their role in cancer

Emily L. Gill; Khushbu Patel; Dinesh Rakheja

doi:10.1016/B978-0-12-824302-2.00003-5

Oncometabolites and their role in cancer

Emily L. Gill, Khushbu Patel, Dinesh Rakheja

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

D-2-hydroxyglutarate (D2HG), L-2-hydroxyglutarate (L2HG), succinate, and fumarate are structurally similar and share metabolic proximity in the tricarboxylic acid cycle. Owing to these similarities they promote tumorigenesis in cancer cells through similar biological mechanisms. This chapter summarizes the role of these canonical oncometabolites in cancer along with methods of measuring and detecting altered metabolic signatures in cancer. Targeted and global profiling strategies are outlined along with imaging approaches for oncological exploration. In addition, current laboratory methodologies that can be used to quantify D2HG and L2HG are outlined along with new innovative approaches to identifying cancerous tissue in real-time.

Original language	English (US)
Title of host publication	Cancer Biomarkers
Subtitle of host publication	Clinical Aspects and Laboratory Determination
Publisher	Elsevier
Pages	393-408
Number of pages	16
ISBN (Electronic)	9780128243022
ISBN (Print)	9780128243039
DOIs	https://doi.org/10.1016/B978-0-12-824302-2.00003-5
State	Published - Jan 1 2022

Keywords

2-hydroxyglutarate
D-2-hydroxyglutarate
IDH
L-2-hydroxyglutarate
Oncometabolites
TCA cycle
fumarate
succinate

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-824302-2.00003-5

Cite this

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abstract = "D-2-hydroxyglutarate (D2HG), L-2-hydroxyglutarate (L2HG), succinate, and fumarate are structurally similar and share metabolic proximity in the tricarboxylic acid cycle. Owing to these similarities they promote tumorigenesis in cancer cells through similar biological mechanisms. This chapter summarizes the role of these canonical oncometabolites in cancer along with methods of measuring and detecting altered metabolic signatures in cancer. Targeted and global profiling strategies are outlined along with imaging approaches for oncological exploration. In addition, current laboratory methodologies that can be used to quantify D2HG and L2HG are outlined along with new innovative approaches to identifying cancerous tissue in real-time.",

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N2 - D-2-hydroxyglutarate (D2HG), L-2-hydroxyglutarate (L2HG), succinate, and fumarate are structurally similar and share metabolic proximity in the tricarboxylic acid cycle. Owing to these similarities they promote tumorigenesis in cancer cells through similar biological mechanisms. This chapter summarizes the role of these canonical oncometabolites in cancer along with methods of measuring and detecting altered metabolic signatures in cancer. Targeted and global profiling strategies are outlined along with imaging approaches for oncological exploration. In addition, current laboratory methodologies that can be used to quantify D2HG and L2HG are outlined along with new innovative approaches to identifying cancerous tissue in real-time.

AB - D-2-hydroxyglutarate (D2HG), L-2-hydroxyglutarate (L2HG), succinate, and fumarate are structurally similar and share metabolic proximity in the tricarboxylic acid cycle. Owing to these similarities they promote tumorigenesis in cancer cells through similar biological mechanisms. This chapter summarizes the role of these canonical oncometabolites in cancer along with methods of measuring and detecting altered metabolic signatures in cancer. Targeted and global profiling strategies are outlined along with imaging approaches for oncological exploration. In addition, current laboratory methodologies that can be used to quantify D2HG and L2HG are outlined along with new innovative approaches to identifying cancerous tissue in real-time.

KW - 2-hydroxyglutarate

KW - D-2-hydroxyglutarate

KW - IDH

KW - L-2-hydroxyglutarate

KW - Oncometabolites

KW - TCA cycle

KW - fumarate

KW - succinate

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M3 - Chapter

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BT - Cancer Biomarkers

PB - Elsevier

ER -

Oncometabolites and their role in cancer

Abstract

Keywords

ASJC Scopus subject areas

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