Once daily cefadroxil versus twice-daily cefaclor for treatment of acute urinary tract infections in children

Seventy-four infants and children (ages 1 month to 16 years) were treated with either 30 mg/kg of cefadroxil once a day or 15 mg/kg of cefaclor twice a day for 10 days. The patients were followed up with urine cultures at 2-5, 12-15 and 24-30 days after completion of therapy. Thirty-six received cefadroxil and 38 cefaclor and each group were well matched with regard to age, sex and temperature. Eighty-nine per cent of infection pathogens were Escherichia coli. The rates of recurrence after treatment were similar for each treatment group (cefadroxil 13-9%, cefaclor 10-5%). The once daily dosing of cefadroxil was considered an advantage in assuring patient compliance.