On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Nenad Bogdanovic; Lionel Bretillon; Erik G. Lund; Ulf Diczfalusy; Lars Lannfelt; Bengt Winblad; David W. Russell; Ingemar Björkhem

doi:10.1016/S0304-3940(01)02277-7

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Nenad Bogdanovic, Lionel Bretillon, Erik G. Lund, Ulf Diczfalusy, Lars Lannfelt, Bengt Winblad, David W. Russell, Ingemar Björkhem

Molecular Genetics

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.

Original language	English (US)
Pages (from-to)	45-48
Number of pages	4
Journal	Neuroscience letters
Volume	314
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3940(01)02277-7
State	Published - Nov 13 2001

Keywords

Alzheimer's disease
Cerebral cholesterol
Cholesterol 24S-hydroxylase
Cytochrome P-450
Oxysterols

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(01)02277-7

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title = "On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells",

abstract = "Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.",

keywords = "Alzheimer's disease, Cerebral cholesterol, Cholesterol 24S-hydroxylase, Cytochrome P-450, Oxysterols",

author = "Nenad Bogdanovic and Lionel Bretillon and Lund, {Erik G.} and Ulf Diczfalusy and Lars Lannfelt and Bengt Winblad and Russell, {David W.} and Ingemar Bj{\"o}rkhem",

note = "Funding Information: This work was supported by grants from The Swedish Medical Research Council, The Swedish Heart-Lung Foundation, The Foundation for Geriatric Diseases, Karolinska Institutet, The Alzheimer Foundation, and The U.S. National Institute of Health (HL 20948).",

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AU - Bogdanovic, Nenad

AU - Bretillon, Lionel

AU - Lund, Erik G.

AU - Diczfalusy, Ulf

AU - Lannfelt, Lars

AU - Winblad, Bengt

AU - Russell, David W.

AU - Björkhem, Ingemar

N1 - Funding Information: This work was supported by grants from The Swedish Medical Research Council, The Swedish Heart-Lung Foundation, The Foundation for Geriatric Diseases, Karolinska Institutet, The Alzheimer Foundation, and The U.S. National Institute of Health (HL 20948).

PY - 2001/11/13

Y1 - 2001/11/13

N2 - Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.

AB - Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.

KW - Alzheimer's disease

KW - Cerebral cholesterol

KW - Cholesterol 24S-hydroxylase

KW - Cytochrome P-450

KW - Oxysterols

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On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Abstract

Keywords

ASJC Scopus subject areas

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