Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects (OEIS) in Triplet Pregnancy after IVF and CVS

Alan L. Shanske; Sumati Pande; Karim Aref; Carlos Vega-Rich; Luc Brion; Sandra Reznik; Ilan E. Timor-Tritsch

doi:10.1002/bdra.10058

Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects (OEIS) in Triplet Pregnancy after IVF and CVS

Alan L. Shanske, Sumati Pande, Karim Aref, Carlos Vega-Rich, Luc Brion, Sandra Reznik, Ilan E. Timor-Tritsch

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

BACKGROUND: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare sporadic condition. CASE: We identified an infant with major malformations resembling OEIS. He was the product of a 30-week triplet pregnancy conceived by in vitro fertilization (IVF) and evaluated by chorionic villi sampling (CVS). In this article, we review the possible pathogenetic mechanisms in this case, including IVF, multiple gestation, trauma to the uterus or uterine vessels following CVS, and placenta accreta. CONCLUSIONS: We conclude that the cumulative effects of all or some of these factors may have resulted in uteroplacental insufficiency adequate to produce this phenotype. This case provides additional evidence for the uterine vascular pathogenesis of OEIS complex in humans.

Original language	English (US)
Pages (from-to)	467-471
Number of pages	5
Journal	Birth Defects Research Part A - Clinical and Molecular Teratology
Volume	67
Issue number	6
DOIs	https://doi.org/10.1002/bdra.10058
State	Published - Jun 1 2003

Keywords

Bladder exstrophy
CVS
Imperforate anus
Limb defect
OEIS
Omphalocele
Spinal defects
Twins
WF

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Embryology
Developmental Biology

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10.1002/bdra.10058

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title = "Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects (OEIS) in Triplet Pregnancy after IVF and CVS",

abstract = "BACKGROUND: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare sporadic condition. CASE: We identified an infant with major malformations resembling OEIS. He was the product of a 30-week triplet pregnancy conceived by in vitro fertilization (IVF) and evaluated by chorionic villi sampling (CVS). In this article, we review the possible pathogenetic mechanisms in this case, including IVF, multiple gestation, trauma to the uterus or uterine vessels following CVS, and placenta accreta. CONCLUSIONS: We conclude that the cumulative effects of all or some of these factors may have resulted in uteroplacental insufficiency adequate to produce this phenotype. This case provides additional evidence for the uterine vascular pathogenesis of OEIS complex in humans.",

keywords = "Bladder exstrophy, CVS, Imperforate anus, Limb defect, OEIS, Omphalocele, Spinal defects, Twins, WF",

author = "Shanske, {Alan L.} and Sumati Pande and Karim Aref and Carlos Vega-Rich and Luc Brion and Sandra Reznik and Timor-Tritsch, {Ilan E.}",

year = "2003",

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doi = "10.1002/bdra.10058",

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AU - Shanske, Alan L.

AU - Pande, Sumati

AU - Aref, Karim

AU - Vega-Rich, Carlos

AU - Brion, Luc

AU - Reznik, Sandra

AU - Timor-Tritsch, Ilan E.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - BACKGROUND: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare sporadic condition. CASE: We identified an infant with major malformations resembling OEIS. He was the product of a 30-week triplet pregnancy conceived by in vitro fertilization (IVF) and evaluated by chorionic villi sampling (CVS). In this article, we review the possible pathogenetic mechanisms in this case, including IVF, multiple gestation, trauma to the uterus or uterine vessels following CVS, and placenta accreta. CONCLUSIONS: We conclude that the cumulative effects of all or some of these factors may have resulted in uteroplacental insufficiency adequate to produce this phenotype. This case provides additional evidence for the uterine vascular pathogenesis of OEIS complex in humans.

AB - BACKGROUND: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare sporadic condition. CASE: We identified an infant with major malformations resembling OEIS. He was the product of a 30-week triplet pregnancy conceived by in vitro fertilization (IVF) and evaluated by chorionic villi sampling (CVS). In this article, we review the possible pathogenetic mechanisms in this case, including IVF, multiple gestation, trauma to the uterus or uterine vessels following CVS, and placenta accreta. CONCLUSIONS: We conclude that the cumulative effects of all or some of these factors may have resulted in uteroplacental insufficiency adequate to produce this phenotype. This case provides additional evidence for the uterine vascular pathogenesis of OEIS complex in humans.

KW - Bladder exstrophy

KW - CVS

KW - Imperforate anus

KW - Limb defect

KW - OEIS

KW - Omphalocele

KW - Spinal defects

KW - Twins

KW - WF

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Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects (OEIS) in Triplet Pregnancy after IVF and CVS

Abstract

Keywords

ASJC Scopus subject areas

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