Human loss-of-function gene variants in GPR120 have recently been identified that confer increased risk for obesity and metabolic syndrome. In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.
|Original language||English (US)|
|Number of pages||2|
|State||Published - May 2 2012|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology