TY - JOUR
T1 - Olfactory identification in young relatives at risk for schizophrenia
AU - Keshavan, Matcheri S.
AU - Vora, Anvi
AU - Montrose, Debra
AU - Diwadkar, Vaibhav A.
AU - Sweeney, John
PY - 2009/6
Y1 - 2009/6
N2 - Objective: Olfactory identification deficits (OIDs) are seen in schizophrenia, but it is unclear whether they are state- or trait-related. Methods: We examined the prevalence of OIDs, as assessed by the University of Pennsylvania Smell Identification Test (UPSIT), and their correlations with prodromal symptoms in young relatives at risk for schizophrenia or schizoaffective disorder (HR-S). Results: UPSIT scores were lower in HR- S than in healthy controls, but were non-significant after covarying the effects of age, gender and IQ. OID deficits in HR-S were correlated, after covarying out the effects of age and IQ, with prodromal disorganisation. Conclusion: The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation.
AB - Objective: Olfactory identification deficits (OIDs) are seen in schizophrenia, but it is unclear whether they are state- or trait-related. Methods: We examined the prevalence of OIDs, as assessed by the University of Pennsylvania Smell Identification Test (UPSIT), and their correlations with prodromal symptoms in young relatives at risk for schizophrenia or schizoaffective disorder (HR-S). Results: UPSIT scores were lower in HR- S than in healthy controls, but were non-significant after covarying the effects of age, gender and IQ. OID deficits in HR-S were correlated, after covarying out the effects of age and IQ, with prodromal disorganisation. Conclusion: The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation.
KW - Cognition
KW - Olfactory identification
KW - Prodrome
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=68049146024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049146024&partnerID=8YFLogxK
U2 - 10.1111/j.1601-5215.2009.00390.x
DO - 10.1111/j.1601-5215.2009.00390.x
M3 - Article
C2 - 21909191
AN - SCOPUS:68049146024
SN - 0924-2708
VL - 21
SP - 121
EP - 124
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
IS - 3
ER -