Ocular motor signatures of cognitive dysfunction in multiple sclerosis

Joanne Fielding, Meaghan Clough, Shin C Beh, Lynette Millist, Derek Sears, Ashley N. Frohman, Nathaniel Lizak, Jayne Lim, Scott Kolbe, Robert L. Rennaker, Teresa C. Frohman, Owen B. White, Elliot Frohman

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The anatomical and functional overlap between ocular motor command circuitry and the higher-order networks that form the scaffolding for cognition makes for a compelling hypothesis that measures of ocular motility could provide a means to sensitively interrogate cognitive dysfunction in people with multiple sclerosis (MS). Such an approach may ultimately provide objective and reproducible measures of cognitive dysfunction that offer an innovative capability to refine diagnosis, improve prognostication, and more accurately codify disease burden. A further dividend may be the validation and application of biomarkers that can be used in studies aimed at identifying and monitoring preventative, protective and even restorative properties of novel neurotherapeutics in MS. This Review discusses the utility of ocular motor measures in patients with MS to characterize disruption to wide-ranging networks that support cognitive function.

Original languageEnglish (US)
Pages (from-to)637-645
Number of pages9
JournalNature Reviews Neurology
Issue number11
StatePublished - Nov 1 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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