Obesity-related metabolic risk in sedentary hispanic adolescent girls with normal bmi

Gert Jan van der Heijden, Zhiyue J. Wang, Zili D. Chu, Morey Haymond, Pieter J.J. Sauer, Agneta L. Sunehag

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat ≥ 27%; n = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; n = 8). Plasma concentrations of glucose, insulin, adiponectin, leptin and Hs-CRP were determined. Insulin resistance was calculated using an oral glucose tolerance test. Body fat % was measured by DXA and subcutaneous, visceral and hepatic fat by MRI/MRS. The N-BMI-HF girls had increased abdominal and hepatic fat content and increased insulin resistance, plasma leptin and Hs-CRP concentrations (p < 0.05) as compared to their N-BMI-NF counterparts. In N-BMI girls, insulin resistance, plasma insulin and leptin correlated with BMI and body fat % (p < 0.05). This research confirms the necessity of the development of BMI and body fat % cut-off criteria per sex, age and racial/ethnic group based on metabolic risk factors to optimize the effectiveness of metabolic risk screening procedures.

Original languageEnglish (US)
Article number79
Issue number6
StatePublished - Jun 2018


  • Abdominal fat
  • BMI
  • Body fat
  • Hispanic
  • Insulin resistance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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