TY - JOUR
T1 - Obesity and Atrial Fibrillation Prevalence, Pathogenesis, and Prognosis
T2 - Effects of Weight Loss and Exercise
AU - Lavie, Carl J.
AU - Pandey, Ambarish
AU - Lau, Dennis H.
AU - Alpert, Martin A.
AU - Sanders, Prashanthan
N1 - Funding Information:
Dr. Sanders is supported by a Practitioner Fellowship from the National Health and Medical Research Council of Australia. Dr. Lavie is author of the book The Obesity Paradox ; and has served as a promotional speaker and consultant for Bristol-Myers Squibb, Pfizer, and Boehringer Ingelheim. Dr Lau has received lecture and/or consulting fees from St. Jude Medical, Boehringer Ingelheim, Bayer, and Pfizer. Dr. Sanders has been on advisory boards of Biosense Webster, Medtronic, St. Jude Medical, Boston Scientific, and CathRx; has received lecture and/or consulting fees from Biosense Webster, Medtronic, St. Jude Medical, and Boston Scientific; and has received research funding from Medtronic, St. Jude Medical, Boston Scientific, Biotronik, and Sorin. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2017 American College of Cardiology Foundation
PY - 2017/10/17
Y1 - 2017/10/17
N2 - Both obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events. Obesity has adverse effects on cardiovascular hemodynamics and cardiac structure and function, and increases the prevalence of AF, partly related to electroanatomic remodeling in obese patients. However, numerous studies, including in AF, have demonstrated an obesity paradox, where overweight and obese patients with these disorders have a better prognosis than do leaner patients with the same degree of severity of cardiovascular disease/AF. In this paper, the authors discuss special issues regarding AF in obesity, as well as the evidence that despite the presence of an obesity paradox, there are benefits of weight loss, physical activity/exercise training, and increases in cardiorespiratory fitness on the prognosis of obese patients with AF.
AB - Both obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events. Obesity has adverse effects on cardiovascular hemodynamics and cardiac structure and function, and increases the prevalence of AF, partly related to electroanatomic remodeling in obese patients. However, numerous studies, including in AF, have demonstrated an obesity paradox, where overweight and obese patients with these disorders have a better prognosis than do leaner patients with the same degree of severity of cardiovascular disease/AF. In this paper, the authors discuss special issues regarding AF in obesity, as well as the evidence that despite the presence of an obesity paradox, there are benefits of weight loss, physical activity/exercise training, and increases in cardiorespiratory fitness on the prognosis of obese patients with AF.
KW - cardiac arrhythmia
KW - cardiovascular diseases
KW - fat
KW - fitness
KW - heart rhythm
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U2 - 10.1016/j.jacc.2017.09.002
DO - 10.1016/j.jacc.2017.09.002
M3 - Review article
C2 - 29025560
AN - SCOPUS:85031764424
SN - 0735-1097
VL - 70
SP - 2022
EP - 2035
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 16
ER -