Nylon and nylon blend nanotubes and nanorods

Valentina Simonetti, Jason Y. Park, Nicholas J. Panaro, Larry J. Kricka

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Nylon nanorods and nanotubes (200 nm diameter) were fabricated by the membrane wetting technique (solvent and melt wetting) from a range of nylons (6; 6,6; 6,9; 6,10; 6,12; 11; 12, 6(3)T) and nylon blended with different dyes (Nylon Cast Blue, Nylon 6/6 Black) or with molybdenum disulfide (Nylon cast MDS). The 65-μm long nylon nanotubes and nanorods were characterized by scanning electron microscopy. The nanoscale nylon 6,6 served as an effective high surface area alternative to a nylon membrane as a solid support in a chemiluminescent assay for nylon-bound biotinylated nucleic acids based on streptavidin- alkaline phosphatase and chemiluminescent detection of the bound alkaline phosphatase label with the dioxetane substrate, CDP-Star. Layer-by-layer deposition of the cationic polymer (Sapphire-II™; Tropix) onto the nylon 6,6 nanostructures prior to UV-cross-linking with biotinylated DNA resulted in further enhancement of binding and detection of biotinylated DNA.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalJournal of Nanoparticle Research
Issue number2
StatePublished - Feb 1 2008


  • Chemiluminescence
  • Membrane wetting
  • Nanobiotechnology
  • Nanorod
  • Nanotube
  • Nylon
  • Nylon blend
  • Synthesis

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • Atomic and Molecular Physics, and Optics
  • Modeling and Simulation
  • General Materials Science
  • Condensed Matter Physics


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