Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment

Jane F. Ferguson; Hooman Allayee; Robert E. Gerszten; Folami Ideraabdullah; Penny M. Kris-Etherton; José M. Ordovás; Eric B. Rimm; Thomas J. Wang; Brian J. Bennett

doi:10.1161/HCG.0000000000000030

Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment

Jane F. Ferguson, Hooman Allayee, Robert E. Gerszten, Folami Ideraabdullah, Penny M. Kris-Etherton, José M. Ordovás, Eric B. Rimm, Thomas J. Wang, Brian J. Bennett

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.

Original language	English (US)
Pages (from-to)	291-313
Number of pages	23
Journal	Circulation: Cardiovascular Genetics
Volume	9
Issue number	3
DOIs	https://doi.org/10.1161/HCG.0000000000000030
State	Published - Jun 1 2016
Externally published	Yes

Keywords

AHA Scientific Statements
diet
metagenomics
microbiota
nutrigenetics
nutrigenomics
nutritional status

ASJC Scopus subject areas

Genetics
Cardiology and Cardiovascular Medicine
Genetics(clinical)

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10.1161/HCG.0000000000000030

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Ferguson, J. F., Allayee, H., Gerszten, R. E., Ideraabdullah, F., Kris-Etherton, P. M., Ordovás, J. M., Rimm, E. B., Wang, T. J., & Bennett, B. J. (2016). Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment. Circulation: Cardiovascular Genetics, 9(3), 291-313. https://doi.org/10.1161/HCG.0000000000000030

Ferguson, JF, Allayee, H, Gerszten, RE, Ideraabdullah, F, Kris-Etherton, PM, Ordovás, JM, Rimm, EB, Wang, TJ & Bennett, BJ 2016, 'Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment', Circulation: Cardiovascular Genetics, vol. 9, no. 3, pp. 291-313. https://doi.org/10.1161/HCG.0000000000000030

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Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment

Abstract

Keywords

ASJC Scopus subject areas

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