TY - JOUR
T1 - Nutrient intake and cerebral metabolism in healthy middle-aged adults
T2 - Implications for cognitive aging
AU - Oleson, Stephanie
AU - Gonzales, Mitzi M.
AU - Tarumi, Takashi
AU - Davis, Jaimie N.
AU - Cassill, Carolyn K.
AU - Tanaka, Hirofumi
AU - Haley, Andreana P.
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/9/14
Y1 - 2017/9/14
N2 - Objectives: Growing evidence suggests dietary factors influence cognition, but the effects of nutrient intake on cerebral metabolism in adults are currently unknown. The present study investigated the relationship between major macronutrient intake (fat, carbohydrate, and protein) and cerebral neurochemical profiles in middle-aged adults. Methods: Thirty-six adults recorded dietary intake for 3 days prior to completing cognitive testing and a proton magnetic resonance spectroscopy (1H-MRS) scan. 1H-MRS of occipitoparietal gray matter was used to assess glutamate (Glu), N-acetyl-aspartate (NAA), choline (Cho), and myo-inositol (mI) relative to creatine (Cr) levels. Results: Regression analyses revealed that high intake of polyunsaturated fatty acids (PUFAs) was associated with lower cerebral Glu/Cr (P = 0.005), and high intake of saturated fat (SFA) was associated with poorer memory function (P = 0.030) independent of age, sex, education, estimated intelligence, total caloric intake, and body mass index. Discussion: In midlife, greater PUFA intake (ω-3 and ω-6) may be associated with lower cerebral glutamate, potentially indicating more efficient cellular reuptake of glutamate. SFA intake, on the other hand, was linked with poorer memory performance. These results suggest that dietary fat intake modification may be an important intervention target for the prevention of cognitive decline.
AB - Objectives: Growing evidence suggests dietary factors influence cognition, but the effects of nutrient intake on cerebral metabolism in adults are currently unknown. The present study investigated the relationship between major macronutrient intake (fat, carbohydrate, and protein) and cerebral neurochemical profiles in middle-aged adults. Methods: Thirty-six adults recorded dietary intake for 3 days prior to completing cognitive testing and a proton magnetic resonance spectroscopy (1H-MRS) scan. 1H-MRS of occipitoparietal gray matter was used to assess glutamate (Glu), N-acetyl-aspartate (NAA), choline (Cho), and myo-inositol (mI) relative to creatine (Cr) levels. Results: Regression analyses revealed that high intake of polyunsaturated fatty acids (PUFAs) was associated with lower cerebral Glu/Cr (P = 0.005), and high intake of saturated fat (SFA) was associated with poorer memory function (P = 0.030) independent of age, sex, education, estimated intelligence, total caloric intake, and body mass index. Discussion: In midlife, greater PUFA intake (ω-3 and ω-6) may be associated with lower cerebral glutamate, potentially indicating more efficient cellular reuptake of glutamate. SFA intake, on the other hand, was linked with poorer memory performance. These results suggest that dietary fat intake modification may be an important intervention target for the prevention of cognitive decline.
KW - Aging
KW - Diet
KW - Executive function
KW - Memory
KW - Polyunsaturated fat
KW - Proton magnetic resonance spectroscopy
KW - Saturated fat
UR - http://www.scopus.com/inward/record.url?scp=84978481201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978481201&partnerID=8YFLogxK
U2 - 10.1080/1028415X.2016.1186341
DO - 10.1080/1028415X.2016.1186341
M3 - Article
C2 - 27237189
AN - SCOPUS:84978481201
SN - 1028-415X
VL - 20
SP - 489
EP - 496
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 8
ER -